Cell Biology Antibodies 7

Anti-RTN1 Antibody (CAB16427)

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SKU:
CAB16427
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RTN1 Antibody
Antibody SKU:CAB16427
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_066959.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_066959.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TGVA GVSS AMDH TFST TSKD GEGS CYTS LISD ICYP PQED STYF TGIL QKEN GHVT ISES PEEL GTPG PSLP DVPG IESR GLFS SDSG IEMT PAES TEVN KILA DPLD QMKA EAYK YIDI TRPE EVKH QEQH HPEL EDKD LDFK NKDT DISI KPEG VREP DKPA PVEG KIIK DHLL EEST FAPY IDDL SEEQ RRAP QITT PVKI TLTE IEPS VETT TQEK TPEK QDIC LKPS PDTV PTVT VSEP EDDS PGSI TPPS SGTE P
Gene ID:6252
Uniprot:Q16799
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:23kDa/38kDa/83kDa
Observed MW:24kDa
Synonyms:RTN1, NSP
Background:This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:RTN1: May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; Cell development/differentiation

Chromosomal Location of Human Ortholog: 14q23.1

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane

Molecular Function:protein binding

Biological Process: neuron differentiation

NCBI Summary:This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
UniProt Code:Q16799
NCBI GenInfo Identifier:12643733
NCBI Gene ID:6252
NCBI Accession:Q16799.1
UniProt Related Accession:Q16799
Molecular Weight:84 kDa
NCBI Full Name:Reticulon-1
NCBI Synonym Full Names:reticulon 1
NCBI Official Symbol:RTN1  
NCBI Official Synonym Symbols:NSP  
NCBI Protein Information:reticulon-1
UniProt Protein Name:Reticulon-1
UniProt Synonym Protein Names:Neuroendocrine-specific protein
Protein Family:Reticulon
UniProt Gene Name:RTN1  
UniProt Entry Name:RTN1_HUMAN
Anti-RTN1 Antibody (CAB16427)Western blot analysis of extracts of mouse lung, using RTN1 antibody (CAB16427) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5 min.
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