Cell Biology Antibodies 13
Anti-RTF1 Antibody (CAB17657)
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- SKU:
- CAB17657
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RTF1 Antibody |
| Antibody SKU: | CAB17657 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human RTF1 (NP_055953.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, HeLa, Jurkat, SW620, COS-7 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human RTF1 (NP_055953.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LAKK QPLK TSEV YSDD EEEE EDDK SSEK SDRS SRTS SSDE EEEK EEIP PKSQ PVSL PEEL NRVR LSRH KLER WCHM PFFA KTVT GCFV RIGI GNHN SKPV Y |
| Gene ID: | 23168 |
| Uniprot: | Q92541 |
| Cellular Location: | |
| Calculated MW: | 80kDa |
| Observed MW: | 100kDa |
 | Western blot - RTF1 Polyclonal Antibody (CAB17657) |
| Synonyms: | GTL7, KIAA0252, RTF1 |
| Background: | This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010] |
| UniProt Protein Function: | RTF1: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single- stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 15q15.1 Cellular Component: nucleolus Molecular Function:protein binding; single-stranded DNA binding Biological Process: Wnt receptor signaling pathway; endodermal cell fate commitment; positive regulation of RNA elongation from RNA polymerase II promoter; stem cell maintenance; transcription initiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation Disease: Congenital Disorder Of Glycosylation, Type In |
| NCBI Summary: | This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q92541 |
| NCBI GenInfo Identifier: | 313104316 |
| NCBI Gene ID: | 23168 |
| NCBI Accession: | Q92541.4 |
| UniProt Secondary Accession: | Q92541,Q96BX6, |
| UniProt Related Accession: | Q92541 |
| Molecular Weight: | 710 |
| NCBI Full Name: | RNA polymerase-associated protein RTF1 homolog |
| NCBI Synonym Full Names: | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) |
| NCBI Official Symbol: | RTF1 |
| NCBI Official Synonym Symbols: | GTL7; KIAA0252 |
| NCBI Protein Information: | RNA polymerase-associated protein RTF1 homolog; ortholog of mouse gene trap locus 7 |
| UniProt Protein Name: | RNA polymerase-associated protein RTF1 homolog |
| Protein Family: | Replication termination factor |
| UniProt Gene Name: | RTF1 |
| UniProt Entry Name: | RTF1_HUMAN |
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