Anti-RRP8 Antibody (CAB20557)

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SKU:
CAB20557
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NML
Synonyms:
KIAA0409

Description

Product Name:RRP8 Rabbit pAb
Product Code:CAB20557
Size:50uL, 100uL
Synonyms:NML, KIAA0409
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human RRP8.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse kidney, Mouse spleen, Rat kidney, Rat thymus
Immunogen:Recombinant protein of human RRP8.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23378
Uniprot:O43159
Calculated MW:50kDa
Observed MW:58KDa
UniProt Protein Function:RRP8: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Belongs to the methyltransferase superfamily. RRP8 family. Protein type: Nucleolus; RNA-binding; EC 2.1.1.- Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: chromatin silencing complex; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane Molecular Function: methylated histone residue binding; protein binding; S-adenosylmethionine-dependent methyltransferase activity Biological Process: cellular response to glucose starvation; chromatin modification; chromatin silencing at rDNA; gene expression; methylation; negative regulation of gene expression, epigenetic; regulation of gene expression, epigenetic; regulation of transcription by glucose; rRNA processing; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
UniProt Code:O43159
NCBI GenInfo Identifier:62900343
NCBI Gene ID:23378
NCBI Accession:O43159.2
UniProt Secondary Accession:O43159,Q7KZ78, Q9BVM6
UniProt Related Accession:O43159
Molecular Weight:50,715 Da
NCBI Full Name:Ribosomal RNA-processing protein 8
NCBI Synonym Full Names:ribosomal RNA processing 8, methyltransferase, homolog (yeast)
NCBI Official Symbol:RRP8  
NCBI Official Synonym Symbols:NML; KIAA0409  
NCBI Protein Information:ribosomal RNA-processing protein 8
UniProt Protein Name:Ribosomal RNA-processing protein 8
UniProt Synonym Protein Names:Cerebral protein 1; Nucleomethylin
Protein Family:25S rRNA
UniProt Gene Name:RRP8  
UniProt Entry Name:RRP8_HUMAN
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