Epigenetics & Nuclear Signaling Antibodies 4
Anti-RRM2B Antibody (CAB8020)
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- SKU:
- CAB8020
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | RRM2B Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8020 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human RRM2B (NP_056528.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human RRM2B (NP_056528.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGDP ERPE AAGL DQDE RSSS DTNE SEIK SNEE PLLR KSSR RFVI FPIQ YPDI WKMY KQAQ ASFW TAEE VDLS KDLP HWNK LKAD EKYF ISHI LAFF AASD GIVN ENLV ERFS QEVQ VPEA RCFY GFQI LIEN VHSE MYSL LIDT YIRD PKKR EFLF NAIE TMPY VKKK ADWA LRWI ADRK STFG ERVV AFAA VEGV FFSG SFAA IFWL KKRG LMPG LTFS NELI SRDE GLHC DFAC LMFQ YLVN KPSE ERVR EIIV DAVK IEQE FLTE ALPV GLIG MNCI LMKQ YIEF VADR LLVE LGFS KVFQ AENP FDFM ENIS LEGK TNFF EKRV SEYQ RFAV MAET TDNV FTLD ADF |
| Gene ID: | 50484 |
| Uniprot: | Q7LG56 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 4kDa/7kDa/15kDa/34kDa/40kDa/48kDa |
| Observed MW: | Refer to figures |
| Synonyms: | RRM2B, MTDPS8A, MTDPS8B, P53R2 |
| Background: | This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. |
| NCBI Summary: | This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010] |
| UniProt Code: | Q7LG56 |
| NCBI GenInfo Identifier: | 74727333 |
| NCBI Gene ID: | 50484 |
| NCBI Accession: | Q7LG56.1 |
| UniProt Secondary Accession: | Q7LG56,Q17R22, Q75PQ6, Q75PQ7, Q75PY8, Q75PY9, Q86YE3 Q9NPD6, Q9NTD8, Q9NUW3, B4E2N4, |
| UniProt Related Accession: | Q7LG56 |
| Molecular Weight: | 48,787 Da |
| NCBI Full Name: | Ribonucleoside-diphosphate reductase subunit M2 B |
| NCBI Synonym Full Names: | ribonucleotide reductase regulatory TP53 inducible subunit M2B |
| NCBI Official Symbol: | RRM2B |
| NCBI Official Synonym Symbols: | P53R2; MTDPS8A; MTDPS8B |
| NCBI Protein Information: | ribonucleoside-diphosphate reductase subunit M2 B |
| UniProt Protein Name: | Ribonucleoside-diphosphate reductase subunit M2 B |
| UniProt Synonym Protein Names: | TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2 |
| Protein Family: | Ribonucleoside-diphosphate reductase |
| UniProt Gene Name: | RRM2B |
| UniProt Entry Name: | RIR2B_HUMAN |
 | Immunofluorescence analysis of A549 cells using RRM2B antibody (CAB8020). Blue: DAPI for nuclear staining. |
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