Epigenetics & Nuclear Signaling Antibodies 5
Anti-RRM2 Antibody (CAB3424)
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- SKU:
- CAB3424
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-RRM2 Antibody |
| Antibody SKU: | CAB3424 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human RRM2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, A375, Mouse liver, Rat liver |
| Immunogen: | A synthesized peptide derived from human RRM2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6241 |
| Uniprot: | P31350 |
| Cellular Location: | |
| Calculated MW: | 45kDa |
| Observed MW: | 45KDa |
| Synonyms: | R2, RR2, RR2M |
| Background: | This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] |
| UniProt Protein Function: | RRM2: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family. |
| UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - glutathione; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; EC 1.17.4.1; Oxidoreductase Chromosomal Location of Human Ortholog: 2p25-p24 Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol Molecular Function:protein binding; metal ion binding; ribonucleoside-diphosphate reductase activity Biological Process: G1/S-specific transcription in mitotic cell cycle; deoxyribonucleoside diphosphate metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; deoxyribonucleotide biosynthetic process; protein heterotetramerization; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle |
| NCBI Summary: | This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P31350 |
| NCBI GenInfo Identifier: | 400979 |
| NCBI Gene ID: | 6241 |
| NCBI Accession: | P31350.1 |
| UniProt Secondary Accession: | P31350,Q5WRU7, B2R9B5, J3KP43, |
| UniProt Related Accession: | P31350 |
| Molecular Weight: | 389 |
| NCBI Full Name: | Ribonucleoside-diphosphate reductase subunit M2 |
| NCBI Synonym Full Names: | ribonucleotide reductase M2 |
| NCBI Official Symbol: | RRM2 |
| NCBI Official Synonym Symbols: | R2; RR2; RR2M |
| NCBI Protein Information: | ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; ribonucleotide reductase M2 polypeptide |
| UniProt Protein Name: | Ribonucleoside-diphosphate reductase subunit M2 |
| UniProt Synonym Protein Names: | Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit |
| Protein Family: | Ribonucleoside-diphosphate reductase |
| UniProt Gene Name: | RRM2 |
| UniProt Entry Name: | RIR2_HUMAN |
 | Western blot - RRM2 Rabbit mAb (CAB3424) |
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