Epigenetics & Nuclear Signaling Antibodies 5

Anti-RRM2 Antibody (CAB3424)

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SKU:
CAB3424
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-RRM2 Antibody
Antibody SKU:CAB3424
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human RRM2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, A375, Mouse liver, Rat liver
Immunogen:A synthesized peptide derived from human RRM2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6241
Uniprot:P31350
Cellular Location:
Calculated MW:45kDa
Observed MW:45KDa
Synonyms:R2, RR2, RR2M
Background:This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
UniProt Protein Function:RRM2: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family.
UniProt Protein Details:

Protein type:Other Amino Acids Metabolism - glutathione; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; EC 1.17.4.1; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p25-p24

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function:protein binding; metal ion binding; ribonucleoside-diphosphate reductase activity

Biological Process: G1/S-specific transcription in mitotic cell cycle; deoxyribonucleoside diphosphate metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; deoxyribonucleotide biosynthetic process; protein heterotetramerization; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle

NCBI Summary:This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
UniProt Code:P31350
NCBI GenInfo Identifier:400979
NCBI Gene ID:6241
NCBI Accession:P31350.1
UniProt Secondary Accession:P31350,Q5WRU7, B2R9B5, J3KP43,
UniProt Related Accession:P31350
Molecular Weight:389
NCBI Full Name:Ribonucleoside-diphosphate reductase subunit M2
NCBI Synonym Full Names:ribonucleotide reductase M2
NCBI Official Symbol:RRM2  
NCBI Official Synonym Symbols:R2; RR2; RR2M  
NCBI Protein Information:ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; ribonucleotide reductase M2 polypeptide
UniProt Protein Name:Ribonucleoside-diphosphate reductase subunit M2
UniProt Synonym Protein Names:Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit
Protein Family:Ribonucleoside-diphosphate reductase
UniProt Gene Name:RRM2  
UniProt Entry Name:RIR2_HUMAN
Anti-RRM2 Antibody (CAB3424)Western blot - RRM2 Rabbit mAb (CAB3424)
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