Cell Biology Antibodies 5

Anti-RPS6KA6 Antibody (CAB14876)

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SKU:
CAB14876
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RPS6KA6 Antibody
Antibody SKU:CAB14876
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 646-745 of human RPS6KA6 (NP_055311.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 646-745 of human RPS6KA6 (NP_055311.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GGNW DNIS DGAK DLLS HMLH MDPH QRYT AEQI LKHS WITH RDQL PNDQ PKRN DVSH VVKG AMVA TYSA LTHK TFQP VLEP VAAS SLAQ RRSM KKRT STGL
Gene ID:27330
Uniprot:Q9UK32
Cellular Location:Cytoplasm, Nucleus, cytosol
Calculated MW:83kDa/84kDa
Observed MW:84kDa
Synonyms:RPS6KA6, PP90RSK4, RSK-4, RSK4, S6K-alpha-6, p90RSK6
Background:This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways.
UniProt Protein Function:RSK4: an AGC kinase of the RSK family. Phosphorylates a wide range of substrates including ribosomal protein S6. Implicated in the activation of the mitogen- activated kinase cascade. May play a role in normal neuronal development.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: Xq21

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleolus; nucleoplasm; nucleus

Molecular Function:kinase activity; protein kinase activity; protein serine/threonine kinase activity

Biological Process: central nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of embryonic development; signal transduction

NCBI Summary:This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
UniProt Code:Q9UK32
NCBI GenInfo Identifier:11133131
NCBI Gene ID:27330
NCBI Accession:Q9UK32.1
UniProt Secondary Accession:Q9UK32,Q6FHX2, Q8WX28, Q9H4S6, B2R854, B7ZL90,
UniProt Related Accession:Q9UK32
Molecular Weight:84,093 Da
NCBI Full Name:Ribosomal protein S6 kinase alpha-6
NCBI Synonym Full Names:ribosomal protein S6 kinase A6
NCBI Official Symbol:RPS6KA6  
NCBI Official Synonym Symbols:RSK4; PP90RSK4  
NCBI Protein Information:ribosomal protein S6 kinase alpha-6
UniProt Protein Name:Ribosomal protein S6 kinase alpha-6
UniProt Synonym Protein Names:90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; Ribosomal S6 kinase 4; RSK-4; pp90RSK4
Protein Family:Ribosomal protein S6 kinase
UniProt Gene Name:RPS6KA6  
UniProt Entry Name:KS6A6_HUMAN
Anti-RPS6KA6 Antibody (CAB14876)Western blot analysis of extracts of mouse kidney, using RPS6KA6 antibody (CAB14876) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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