Immunology Antibodies 2
Anti-RPS6KA5 Antibody (CAB5699)
- SKU:
- CAB5699
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-RPS6KA5 Antibody |
| Antibody SKU: | CAB5699 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human RPS6KA5 (NP_004746.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, HeLa, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human RPS6KA5 (NP_004746.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TPDI LGSS GAAV HTCV KATF HAFN KYKR EGFC LQNV DKAP LAKR RKMK KTST STET RSSS SESS HSSS SHSH GKTT PTKT LQPS NPAD SNNP ETLF QFSD S |
| Gene ID: | 9252 |
| Uniprot: | O75582 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 61kDa/81kDa/89kDa |
| Observed MW: | 75kDa |
| Synonyms: | RPS6KA5, MSK1, MSPK1, RLPK |
| Background: |
| UniProt Protein Function: | MSK1: an AGC kinase of the RSK family. Has two kinase domains connected by a regulatory linker region. Enzyme activity requires the presence of both kinase domains. Is phosphorylated and activated by Erk as well as p38 MAPK in response to growth factors and cellular stress. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; MSK subfamily Chromosomal Location of Human Ortholog: 14q31-q32.1 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:ATP binding; histone serine kinase activity (H3-S10 specific); magnesium ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity Biological Process: activation of CREB transcription factor; activation of NF-kappaB transcription factor; axon guidance; epidermal growth factor receptor signaling pathway; histone phosphorylation; inflammatory response; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of cytokine production; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of histone acetylation; positive regulation of histone phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway |
| UniProt Code: | O75582 |
| NCBI GenInfo Identifier: | 37999482 |
| NCBI Gene ID: | 9252 |
| NCBI Accession: | O75582.1 |
| UniProt Secondary Accession: | O75582,O95316, Q96AF7, B7Z2Y5, |
| UniProt Related Accession: | O75582 |
| Molecular Weight: | 81,780 Da |
| NCBI Full Name: | Ribosomal protein S6 kinase alpha-5 |
| NCBI Synonym Full Names: | ribosomal protein S6 kinase A5 |
| NCBI Official Symbol: | RPS6KA5 |
| NCBI Official Synonym Symbols: | MSK1; RLPK; MSPK1 |
| NCBI Protein Information: | ribosomal protein S6 kinase alpha-5 |
| UniProt Protein Name: | Ribosomal protein S6 kinase alpha-5 |
| UniProt Synonym Protein Names: | 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL |
| Protein Family: | Ribosomal protein S6 kinase |
| UniProt Gene Name: | RPS6KA5 |
| UniProt Entry Name: | KS6A5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RPS6KA5 Antibody (CAB5699) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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