Cell Biology Antibodies 8
Anti-RPS19 Antibody (CAB2019)
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- SKU:
- CAB2019
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RPS19 Antibody |
| Antibody SKU: | CAB2019 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human RPS19 (NP_001013.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HL-60, PC-3, MCF7, A-549, 293T, HepG2, SW620, BxPC-3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human RPS19 (NP_001013.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPGV TVKD VNQQ EFVR ALAA FLKK SGKL KVPE WVDT VKLA KHKE LAPY DENW FYTR AAST ARHL YLRG GAGV GSMT KIYG GRQR NGVM PSHF SRGS KSVA RRVL QALE GLKM VEKD QDGG RKLT PQGQ RDLD RIAG QVAA ANKK H |
| Gene ID: | 6223 |
| Uniprot: | P39019 |
| Cellular Location: | Nucleus |
| Calculated MW: | 16kDa |
| Observed MW: | 16kDa |
| Synonyms: | RPS19, DBA, DBA1, S19 |
| Background: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. |
| UniProt Protein Function: | RPS19: Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Defects in RPS19 are the cause of Diamond-Blackfan anemia type 1 (DBA1). DBA1 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S19e family. |
| UniProt Protein Details: | Protein type:Translation; Ribosomal Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleoplasm; ribosome Molecular Function:fibroblast growth factor binding; protein binding; protein homodimerization activity; protein kinase binding; structural constituent of ribosome Biological Process: erythrocyte differentiation; maturation of SSU-rRNA; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); monocyte chemotaxis; mRNA catabolic process, nonsense-mediated decay; nucleolus organization and biogenesis; positive regulation of cell motility; protein tetramerization; response to extracellular stimulus; ribosomal small subunit assembly and maintenance; ribosomal small subunit biogenesis and assembly; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription Disease: Diamond-blackfan Anemia 1 |
| NCBI Summary: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P39019 |
| NCBI GenInfo Identifier: | 730640 |
| NCBI Gene ID: | 6223 |
| NCBI Accession: | P39019.2 |
| UniProt Related Accession: | P39019 |
| Molecular Weight: | 16,060 Da |
| NCBI Full Name: | 40S ribosomal protein S19 |
| NCBI Synonym Full Names: | ribosomal protein S19 |
| NCBI Official Symbol: | RPS19 |
| NCBI Official Synonym Symbols: | DBA; S19; DBA1 |
| NCBI Protein Information: | 40S ribosomal protein S19 |
| UniProt Protein Name: | 40S ribosomal protein S19 |
| Protein Family: | Ribosomal protein |
| UniProt Gene Name: | RPS19 |
| UniProt Entry Name: | RS19_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RPS19 antibody (CAB2019) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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