Cell Biology Antibodies 10

Anti-RPLP2 Antibody (CAB6974)

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SKU:
CAB6974
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RPLP2 Antibody
Antibody SKU:CAB6974
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human RPLP2 (NP_000995.1).
Application:IF
Recommended Dilution:IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human RPLP2 (NP_000995.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRYV ASYL LAAL GGNS SPSA KDIK KILD SVGI EADD DRLN KVIS ELNG KNIE DVIA QGIG KLAS VPAG GAVA VSAA PGSA APAA GSAP AAAE EKKD EKKE ESEE SDDD MGFG LFD
Gene ID:6181
Uniprot:P05387
Cellular Location:
Calculated MW:11kDa
Observed MW:
Synonyms:RPLP2, D11S2243E, LP2, P2, RPP2
Background:Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
UniProt Protein Function:RPLP2: Plays an important role in the elongation step of protein synthesis. Belongs to the ribosomal protein L12P family.
UniProt Protein Details:

Protein type:Translation; Ribosomal

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: focal adhesion; membrane; cytosol

Molecular Function:structural constituent of ribosome; RNA binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; translational elongation; cellular protein metabolic process; translation; viral reproduction; mRNA catabolic process, nonsense-mediated decay; translational initiation; gene expression; viral transcription; translational termination; viral infectious cycle

NCBI Summary:Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
UniProt Code:P05387
NCBI GenInfo Identifier:133061
NCBI Gene ID:6181
NCBI Accession:P05387.1
UniProt Secondary Accession:P05387,Q6FG96,
UniProt Related Accession:P05387
Molecular Weight:115
NCBI Full Name:60S acidic ribosomal protein P2
NCBI Synonym Full Names:ribosomal protein, large, P2
NCBI Official Symbol:RPLP2  
NCBI Official Synonym Symbols:P2; LP2; RPP2; D11S2243E  
NCBI Protein Information:60S acidic ribosomal protein P2; renal carcinoma antigen NY-REN-44; acidic ribosomal phosphoprotein P2
UniProt Protein Name:60S acidic ribosomal protein P2
UniProt Synonym Protein Names:Renal carcinoma antigen NY-REN-44
UniProt Gene Name:RPLP2  
UniProt Entry Name:RLA2_HUMAN
Anti-RPLP2 Antibody (CAB6974)Immunofluorescence analysis of U2OS cells using RPLP2 antibody (CAB6974). Blue: DAPI for nuclear staining.
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