Cell Biology Antibodies 10
Anti-RPL3 Antibody (CAB6973)
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- SKU:
- CAB6973
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RPL3 Antibody |
| Antibody SKU: | CAB6973 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RPL3 (NP_000958.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RPL3 (NP_000958.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSHR KFSA PRHG SLGF LPRK RSSR HRGK VKSF PKDD PSKP VHLT AFLG YKAG MTHI VREV DRPG SKVN KKEV VEAV TIVE TPPM VVVG IVGY VETP RGLR TFKT VFAE HISD ECKR RFYK NWHK SKKK AFTK YCKK WQDE DGKK QLEK DFSS MKKY CQVI RVIA HTQM RLLP LRQK KAHL MEIQ VNGG TVAE KLDW ARER LEQQ VPVN QVFG QDEM IDVI GVTK GKGY KGVT SRWH TKKL PRKT HRGL RKVA CIGA WHPA |
| Gene ID: | 6122 |
| Uniprot: | P39023 |
| Cellular Location: | Cytoplasm, Nucleus, nucleolus |
| Calculated MW: | 46kDa |
| Observed MW: | 46kDa |
| Synonyms: | RPL3, ASC-1, L3, TARBP-B |
| Background: | Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. |
| UniProt Protein Function: | RPL3: The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Belongs to the ribosomal protein L3P family. |
| UniProt Protein Details: | Protein type:Translation; Nucleolus; Ribosomal Chromosomal Location of Human Ortholog: 22q13 Cellular Component: nucleoplasm; focal adhesion; cytoplasm; nucleolus; nucleus; cytosol Molecular Function:structural constituent of ribosome; RNA binding Biological Process: SRP-dependent cotranslational protein targeting to membrane; translational elongation; cellular protein metabolic process; viral reproduction; translation; translational initiation; mRNA catabolic process, nonsense-mediated decay; gene expression; viral transcription; viral infectious cycle; translational termination |
| NCBI Summary: | Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P39023 |
| NCBI GenInfo Identifier: | 730565 |
| NCBI Gene ID: | 6122 |
| NCBI Accession: | P39023.2 |
| UniProt Secondary Accession: | P39023,Q15548, Q5I0G0, B2RDV9, |
| UniProt Related Accession: | P39023 |
| Molecular Weight: | 403 |
| NCBI Full Name: | 60S ribosomal protein L3 |
| NCBI Synonym Full Names: | ribosomal protein L3 |
| NCBI Official Symbol: | RPL3 |
| NCBI Official Synonym Symbols: | L3; ASC-1; TARBP-B |
| NCBI Protein Information: | 60S ribosomal protein L3; hypothetical protein; HIV-1 TAR RNA-binding protein B; ribosomal protein L3, isoform a |
| UniProt Protein Name: | 60S ribosomal protein L3 |
| UniProt Synonym Protein Names: | HIV-1 TAR RNA-binding protein B; TARBP-B |
| Protein Family: | Ribosomal protein |
| UniProt Gene Name: | RPL3 |
| UniProt Entry Name: | RL3_HUMAN |
 | Western blot analysis of extracts of U-87MG cells, using RPL3 antibody (CAB6973) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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