Cell Biology Antibodies 13
Anti-RP1 Antibody (CAB17526)
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- SKU:
- CAB17526
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RP1 Antibody |
| Antibody SKU: | CAB17526 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human RP1 (NP_006260.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human RP1 (NP_006260.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VYPK GNAK SESR KIST HMSS SSRS QIYS VSSE KTHN NDCY LDYS FVPE KYLA LEKN DSQN LPIY PSED DIEK SIIF NQDG TMTV EMKV RFRI KEEE TIKW TTTV SKTG PSNN DEKS EMSF PGRT ESRS SGLK LAAC SFSA DVSP MERS SNQE GSLA EEIN IQMT DQVA ETCS SASW ENAT VDTD IIQG TQDQ AKHR FYRP PTPG LRRV RQKK SVIG SVTL VSET EVQE KMIG QFSY SEER ESGE NKSE YHM |
| Gene ID: | 6101 |
| Uniprot: | P56715 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | DCDC4A, ORP1, RP1 |
| Background: | This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010] |
| UniProt Protein Function: | Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme. |
| NCBI Summary: | This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010] |
| UniProt Code: | P56715 |
| NCBI GenInfo Identifier: | 5454016 |
| NCBI Gene ID: | 6101 |
| NCBI Accession: | NP_006260.1 |
| UniProt Related Accession: | P56715 |
| Molecular Weight: | 240,661 Da |
| NCBI Full Name: | oxygen-regulated protein 1 |
| NCBI Synonym Full Names: | RP1, axonemal microtubule associated |
| NCBI Official Symbol: | RP1 |
| NCBI Official Synonym Symbols: | ORP1; DCDC4A |
| NCBI Protein Information: | oxygen-regulated protein 1 |
| UniProt Protein Name: | Oxygen-regulated protein 1 |
| UniProt Synonym Protein Names: | Retinitis pigmentosa 1 protein; Retinitis pigmentosa RP1 protein |
| Protein Family: | Oxygen-regulated protein |
| UniProt Gene Name: | RP1 |
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