Cell Biology Antibodies 12

Anti-ROGDI Antibody (CAB9239)

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SKU:
CAB9239
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ROGDI Antibody
Antibody SKU:CAB9239
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ROGDI (NP_078865.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ROGDI (NP_078865.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MATV MAAT AAER AVLE EEFR WLLH DEVH AVLK QLQD ILKE ASLR FTLP GSGT EGPA KQEN FILG SCGT DQVK GVLT LQGD ALSQ ADVN LKMP RNNQ LLHF AFRE DKQW KLQQ IQDA RNHV SQAI YLLT SRDQ SYQF KTGA
Gene ID:79641
Uniprot:Q9GZN7
Cellular Location:Nucleus envelope
Calculated MW:32kDa
Observed MW:32kDa
Synonyms:ROGDI, KTZS
Background:This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:ROGDI: May act as a positive regulator of cell proliferation. Defects in ROGDI are the cause of Kohlschuetter-Toenz syndrome (KTZS). An autosomal recessive disorder characterized by severe global developmental delay, early-onset intractable seizures, spasticity, and amelogenesis imperfecta affecting both primary and secondary teeth and causing yellow or brown discoloration of the teeth. Although the phenotype is consistent, there is variability. Intellectual disability is related to the severity of seizures, and the disorder can thus be considered an epileptic encephalopathy. Some infants show normal development until seizure onset, whereas others are delayed from birth. The most severely affected individuals have profound mental retardation, never acquire speech, and become bedridden early in life. Belongs to the rogdi family.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 16p13.3Cellular Component: nuclear envelope; intracellularBiological Process: positive regulation of cell proliferation; hemopoiesisDisease: Kohlschutter-tonz Syndrome
UniProt Protein Details:
NCBI Summary:This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
UniProt Code:Q9GZN7
NCBI GenInfo Identifier:13375779
NCBI Gene ID:79641
NCBI Accession:NP_078865.1
UniProt Secondary Accession:Q9GZN7,Q6IA00
UniProt Related Accession:Q9GZN7
Molecular Weight:32,254 Da
NCBI Full Name:protein rogdi homolog
NCBI Synonym Full Names:rogdi homolog (Drosophila)
NCBI Official Symbol:ROGDI  
NCBI Official Synonym Symbols:KTZS  
NCBI Protein Information:protein rogdi homolog; leucine zipper domain protein
UniProt Protein Name:Protein rogdi homolog
UniProt Synonym Protein Names:
Protein Family:Protein rogdi
UniProt Gene Name:ROGDI  
UniProt Entry Name:ROGDI_HUMAN
Anti-ROGDI Polyclonal Antibody (CAB9239)Western blot analysis of extracts of various cell lines, using ROGDI antibody (CAB9239) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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