Signal Transduction Antibodies 3
Anti-RNF7 Antibody (CAB7301)
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- SKU:
- CAB7301
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-RNF7 Antibody |
| Antibody SKU: | CAB7301 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human RNF7 (NP_055060.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:20 - 1:50 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human RNF7 (NP_055060.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MADV EDGE ETCA LASH SGSS GSKS GGDK MFSL KKWN AVAM WSWD VECD TCAI CRVQ VMDA CLRC QAEN KQED CVVV WGEC NHSF HNCC MSLW VKQN NRCP LCQQ DWVV QRIG K |
| Gene ID: | 9616 |
| Uniprot: | Q9UBF6 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 9kDa/10kDa/11kDa/12kDa |
| Observed MW: | Refer to figures |
| Synonyms: | RNF7, CKBBP1, ROC2, SAG |
| Background: | The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| UniProt Protein Function: | RNF7: a highly conserved ring finger protein. An essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. The RING-type zinc finger recruits the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. This protein interacts with, and is a substrate of, casein kinase II (CKII). The phosphorylation of this protein by CKII has been shown to promote the degradation of IkappaB-alpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Two alternatively spliced isoforms have been reported. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 3q23 Cellular Component: Cul5-RING ubiquitin ligase complex; cytosol; nucleoplasm Molecular Function:copper ion binding; NEDD8 ligase activity; protein binding Biological Process: protein neddylation; response to redox state |
| NCBI Summary: | The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBF6 |
| NCBI GenInfo Identifier: | 37538003 |
| NCBI Gene ID: | 9616 |
| NCBI Accession: | Q9UBF6.1 |
| UniProt Secondary Accession: | Q9UBF6,Q9BXN8, Q9Y5M7, A8K1H9, A8MTB5, C9JYL3, D3DNF7 D3DNF8, |
| UniProt Related Accession: | Q9UBF6 |
| Molecular Weight: | 10,876 Da |
| NCBI Full Name: | RING-box protein 2 |
| NCBI Synonym Full Names: | ring finger protein 7 |
| NCBI Official Symbol: | RNF7 |
| NCBI Official Synonym Symbols: | SAG; ROC2; CKBBP1 |
| NCBI Protein Information: | RING-box protein 2 |
| UniProt Protein Name: | RING-box protein 2 |
| UniProt Synonym Protein Names: | CKII beta-binding protein 1; CKBBP1; RING finger protein 7; Regulator of cullins 2; Sensitive to apoptosis gene protein |
| UniProt Gene Name: | RNF7 |
 | Immunofluorescence analysis of MCF-7 cells using RNF7 antibody (CAB7301). Blue: DAPI for nuclear staining. |
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