Cell Biology Antibodies 2
Anti-RNF19A Antibody (CAB12036)
- SKU:
- CAB12036
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-RNF19A Antibody |
Antibody SKU: | CAB12036 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 639-838 of human RNF19A (NP_056250.3). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | U-87MG, HepG2, HT-29, HeLa |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 639-838 of human RNF19A (NP_056250.3). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | GSAT RSHA GGSS SGLP EGKS SATK WSKE ATAG KKSK SGKL RKKG NMKI NETR EDMD AQLL EQQS TNSS EFEA PSLS DSMP SVAD SHSS HFSE FSCS DLES MKTS CSHG SSDY HTRF ATVN ILPE VEND RLEN SPHQ CSIS VVTQ TASC SEVS QLNH IAEE HGNN GIKP NVDL YFGD ALKE TNNN HSHQ TMEL KVAI QTEI |
Gene ID: | 25897 |
Uniprot: | Q9NV58 |
Cellular Location: | Cytoplasm, Membrane, Multi-pass membrane protein, centrosome, cytoskeleton, microtubule organizing center |
Calculated MW: | 65kDa/87kDa/90kDa |
Observed MW: | 105kDa |
Synonyms: | RNF19A, RNF19 |
Background: | This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | RNF19: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. Belongs to the RBR family. RNF19 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligaseChromosomal Location of Human Ortholog: 8q22.2Cellular Component: centrosome; cytoplasm; cytosol; ubiquitin ligase complexMolecular Function: transcription factor binding; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activityBiological Process: microtubule cytoskeleton organization and biogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9NV58 |
NCBI GenInfo Identifier: | 116242764 |
NCBI Gene ID: | 25897 |
NCBI Accession: | Q9NV58.3 |
UniProt Secondary Accession: | Q9NV58,Q52LG1, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1 A3KCU9 |
UniProt Related Accession: | Q9NV58 |
Molecular Weight: | 91kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase RNF19A |
NCBI Synonym Full Names: | ring finger protein 19A, RBR E3 ubiquitin protein ligase |
NCBI Official Symbol: | RNF19A |
NCBI Official Synonym Symbols: | RNF19 |
NCBI Protein Information: | E3 ubiquitin-protein ligase RNF19A |
UniProt Protein Name: | E3 ubiquitin-protein ligase RNF19A |
UniProt Synonym Protein Names: | Double ring-finger protein; Dorfin; RING finger protein 19A; p38 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RNF19A |
UniProt Entry Name: |
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