Signal Transduction Antibodies 2

Anti-RNF170 Antibody (CAB15195)

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SKU:
CAB15195
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-RNF170 Antibody
Antibody SKU:CAB15195
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 46-120 of human RNF170 (NP_001153696.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse thymus, Mouse brain, Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 46-120 of human RNF170 (NP_001153696.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RNVH QNIH PENQ ELVR VLRE QLQT EQDA PAAT RQQF YTDM YCPI CLHQ ASFP VETN CGHL FCGA CIIA YWRY GSW
Gene ID:81790
Uniprot:Q96K19
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:13kDa/18kDa/20kDa/22kDa/26kDa/29kDa
Observed MW:30kDa
Synonyms:RNF170, ADSA, SNAX1
Background:This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1, 4, 5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.
NCBI Summary:This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
UniProt Code:Q96K19
NCBI GenInfo Identifier:237858654
NCBI Gene ID:81790
NCBI Accession:NP_112216
UniProt Related Accession:Q96K19
Molecular Weight:30kDa
NCBI Full Name:E3 ubiquitin-protein ligase RNF170 isoform a
NCBI Synonym Full Names:ring finger protein 170
NCBI Official Symbol:RNF170  
NCBI Official Synonym Symbols:ADSA; SNAX1  
NCBI Protein Information:E3 ubiquitin-protein ligase RNF170
UniProt Protein Name:E3 ubiquitin-protein ligase RNF170
UniProt Synonym Protein Names:Putative LAG1-interacting protein; RING finger protein 170
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:RNF170  
UniProt Entry Name:RN170_HUMAN
Anti-RNF170 Antibody (CAB15195)Western blot analysis of extracts of various cell lines, using RNF170 antibody (CAB15195) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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