Cell Biology Antibodies 13

Anti-RNF144A Antibody (CAB17597)

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SKU:
CAB17597
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RNF144A Antibody
Antibody SKU:CAB17597
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 52-179 of human RNF144A (NP_055561.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:A-431, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 52-179 of human RNF144A (NP_055561.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ELLI KEGL ETAI SCPD AACP KQGH LQEN EIEC MVAA EIMQ RYKK LQFE REVL FDPC RTWC PAST CQAV CQLQ DVGL QTPQ PVQC KACR MEFC STCK ASWH PGQG CPET MPIT FLPG ETSA AFKM EEDD
Gene ID:9781
Uniprot:P50876
Cellular Location:
Calculated MW:
Observed MW:38kDa
Anti-RNF144A Antibody (CAB17597)Western blot - RNF144A Polyclonal Antibody (CAB17597)
Synonyms:RNF144, UBCE7IP4, hUIP4, RNF144A
Background:This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]
UniProt Protein Function:RNF144A: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Belongs to the RBR family. RNF144 subfamily.
UniProt Protein Details:

Protein type:Ubiquitin ligase; Ligase; Membrane protein, integral; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 2p25.2

Cellular Component: Golgi apparatus; ubiquitin ligase complex

Molecular Function:ubiquitin conjugating enzyme binding

Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process

NCBI Summary:The protein encoded by this protein contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The mouse counterpart of this protein has been shown to interact with Ube2l3/UbcM4, which is an ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Jul 2008]
UniProt Code:P50876
NCBI GenInfo Identifier:160358924
NCBI Gene ID:9781
NCBI Accession:P50876.2
UniProt Secondary Accession:P50876,Q585H5, D6W4Y6,
UniProt Related Accession:P50876
Molecular Weight:32,890 Da
NCBI Full Name:E3 ubiquitin-protein ligase RNF144A
NCBI Synonym Full Names:ring finger protein 144A
NCBI Official Symbol:RNF144A  
NCBI Official Synonym Symbols:RNF144; UBCE7IP4  
NCBI Protein Information:E3 ubiquitin-protein ligase RNF144A
UniProt Protein Name:E3 ubiquitin-protein ligase RNF144A
UniProt Synonym Protein Names:RING finger protein 144A; UbcM4-interacting protein 4; Ubiquitin-conjugating enzyme 7-interacting protein 4
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:RNF144A  
UniProt Entry Name:R144A_HUMAN
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