Name: Anti-RNF14 Antibody (CAB17311)
Brand: Epigenetics & Nuclear Signaling Antibodies 3
SKU: CAB17311
Availability: OutOfStock

Antibody Name:	Anti-RNF14 Antibody
Antibody SKU:	CAB17311
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 125-474 of human RNF14 (NP_004281.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 125-474 of human RNF14 (NP_004281.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	AWMQ FLKE ETLA YLNI VSPF ELKI GSQK KVQR RTAQ ASPN TELD FGGA AGSD VDQE EIVD ERAV QDVE SLSN LIQE ILDF DQAQ QIKC FNSK LFLC SICF CEKL GSEC MYFL ECRH VYCK ACLK DYFE IQIR DGQV QCLN CPEP KCPS VATP GQVK ELVE AELF ARYD RLLL QSSL DLMA DVVY CPRP CCQL PVMQ EPGC TMGI CSSC NFAF CTLC RLTY HGVS PCKV TAEK LMDL RNEY LQAD EANK RLLD QRYG KRVI QKAL EEME SKEW LEKN SKSC PCCG TPIE KLDG CNKM TCTG CMQY FCWI CMGS LSRA NPYK HFND PGSP CFNR LFYA VDVD DDIW EDEV ED
Gene ID:	9604
Uniprot:	Q9UBS8
Cellular Location:
Calculated MW:
Observed MW:	Refer to figures

Synonyms:	RNF14, ARA54, HFB30, HRIHFB2038, TRIAD2
Background:

UniProt Protein Function:	RNF14: Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription. Belongs to the RBR family. RNF14 subfamily.
UniProt Protein Details:	Protein type:Nuclear receptor co-regulator; EC 6.3.2.-; Ubiquitin conjugating system; Ligase; EC 6.3.2.19; Transcription, coactivator/corepressor; Ubiquitin ligase Chromosomal Location of Human Ortholog: 5q23.3-q31.1 Cellular Component: cytoplasm; nucleus; ubiquitin ligase complex Molecular Function:androgen receptor binding; protein binding; small conjugating protein ligase activity; transcription coactivator activity; ubiquitin conjugating enzyme binding Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription, DNA-dependent; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; signal transduction
NCBI Summary:	The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
UniProt Code:	Q9UBS8
NCBI GenInfo Identifier:	17380293
NCBI Gene ID:	9604
NCBI Accession:	Q9UBS8.1
UniProt Secondary Accession:	Q9UBS8,O94793, Q6IBV0, A0AV26, A6NMR2, A8MTW5, B3KN72 B7ZLV2, D3DQE4,
UniProt Related Accession:	Q9UBS8
Molecular Weight:	39,634 Da
NCBI Full Name:	E3 ubiquitin-protein ligase RNF14
NCBI Synonym Full Names:	ring finger protein 14
NCBI Official Symbol:	RNF14
NCBI Official Synonym Symbols:	ARA54; HFB30; TRIAD2; HRIHFB2038
NCBI Protein Information:	E3 ubiquitin-protein ligase RNF14
UniProt Protein Name:	E3 ubiquitin-protein ligase RNF14
UniProt Synonym Protein Names:	Androgen receptor-associated protein 54; HFB30; RING finger protein 14; Triad2 protein
Protein Family:	E3 ubiquitin-protein ligase
UniProt Gene Name:	RNF14
UniProt Entry Name:	RNF14_HUMAN