Cell Biology Antibodies 18

Anti-RNF128 Antibody (CAB18276)

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SKU:
CAB18276
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RNF128 Antibody
Antibody SKU:CAB18276
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human RNF128.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human RNF128.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:79589
Uniprot:Q8TEB7
Cellular Location:
Calculated MW:46kDa
Observed MW:Refer to figures
Synonyms:GRAIL, RNF128
Background:The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
UniProt Protein Function:RNF128: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural- inducing signals. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 6.3.2.19; EC 6.3.2.-; Ligase; Membrane protein, integral; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: Xq22.3

Molecular Function:protein binding

Biological Process: regulation of protein stability

NCBI Summary:The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TEB7
NCBI GenInfo Identifier:74751443
NCBI Gene ID:79589
NCBI Accession:Q8TEB7.1
UniProt Secondary Accession:Q8TEB7,Q6PH80, Q6ZTJ8, Q96RF3, Q9H5E4, A0PJI4,
UniProt Related Accession:Q8TEB7
Molecular Weight:44,617 Da
NCBI Full Name:E3 ubiquitin-protein ligase RNF128
NCBI Synonym Full Names:ring finger protein 128, E3 ubiquitin protein ligase
NCBI Official Symbol:RNF128  
NCBI Official Synonym Symbols:GRAIL  
NCBI Protein Information:E3 ubiquitin-protein ligase RNF128
UniProt Protein Name:E3 ubiquitin-protein ligase RNF128
UniProt Synonym Protein Names:Gene related to anergy in lymphocytes protein; GRAIL; RING finger protein 128
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:RNF128  
UniProt Entry Name:RN128_HUMAN
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