Immunology Antibodies 2

Anti-RNF125 Antibody (CAB7982)

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SKU:
CAB7982
Product Type:
Antibody
Applications:
IF
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:RNF125 Rabbit Polyclonal Antibody
Antibody SKU:CAB7982
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human RNF125 (NP_060301.2).
Application:IF
Recommended Dilution:IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human RNF125 (NP_060301.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGSV LSTD SGKS APAS ATAR ALER RRDP ELPV TSFD CAVC LEVL HQPV RTRC GHVF CRSC IATS LKNN KWTC PYCR AYLP SEGV PATD VAKR MKSE YKNC AECD TLVC LSEM RAHI RTCQ KYID KYGP LQEL EETA ARCV CPFC QREL YEDS LLDH CITH HRSE RRPV FCPL CRLI PDEN PSSF SGSL IRHL QVSH TLFY DDFI DFNI IEEA LIRR VLDR SLLE YVNH SNTT
Gene ID:54941
Uniprot:Q96EQ8
Cellular Location:
Calculated MW:26kDa
Observed MW:
Synonyms:RNF125, TNORS, TRAC-1, TRAC1
Background:This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.
UniProt Protein Function:RNF125: E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Ligase

Chromosomal Location of Human Ortholog: 18q12.1

Molecular Function:zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: protein ubiquitination; innate immune response; negative regulation of interferon type I production

Disease: Tenorio Syndrome

NCBI Summary:This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]
UniProt Code:Q96EQ8
NCBI GenInfo Identifier:37595555
NCBI Gene ID:54941
NCBI Accession:NP_060301
UniProt Related Accession:Q96EQ8
Molecular Weight:26kDa
NCBI Full Name:E3 ubiquitin-protein ligase RNF125
NCBI Synonym Full Names:ring finger protein 125
NCBI Official Symbol:RNF125  
NCBI Official Synonym Symbols:TNORS; TRAC1; TRAC-1  
NCBI Protein Information:E3 ubiquitin-protein ligase RNF125
UniProt Protein Name:E3 ubiquitin-protein ligase RNF125
UniProt Synonym Protein Names:RING finger protein 125; T-cell RING activation protein 1
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:RNF125  
UniProt Entry Name:RN125_HUMAN
Anti-RNF125 Polyclonal Antibody (CAB7982)Immunofluorescence analysis of A549 cells using RNF125 antibody (CAB7982). Blue: DAPI for nuclear staining.
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