Description
| Antibody Name: | RNF125 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7982 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human RNF125 (NP_060301.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human RNF125 (NP_060301.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGSV LSTD SGKS APAS ATAR ALER RRDP ELPV TSFD CAVC LEVL HQPV RTRC GHVF CRSC IATS LKNN KWTC PYCR AYLP SEGV PATD VAKR MKSE YKNC AECD TLVC LSEM RAHI RTCQ KYID KYGP LQEL EETA ARCV CPFC QREL YEDS LLDH CITH HRSE RRPV FCPL CRLI PDEN PSSF SGSL IRHL QVSH TLFY DDFI DFNI IEEA LIRR VLDR SLLE YVNH SNTT |
| Gene ID: | 54941 |
| Uniprot: | Q96EQ8 |
| Cellular Location: | |
| Calculated MW: | 26kDa |
| Observed MW: |
| Synonyms: | RNF125, TNORS, TRAC-1, TRAC1 |
| Background: | This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. |
| UniProt Protein Function: | RNF125: E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Ligase Chromosomal Location of Human Ortholog: 18q12.1 Molecular Function:zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: protein ubiquitination; innate immune response; negative regulation of interferon type I production Disease: Tenorio Syndrome |
| NCBI Summary: | This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q96EQ8 |
| NCBI GenInfo Identifier: | 37595555 |
| NCBI Gene ID: | 54941 |
| NCBI Accession: | NP_060301 |
| UniProt Related Accession: | Q96EQ8 |
| Molecular Weight: | 26kDa |
| NCBI Full Name: | E3 ubiquitin-protein ligase RNF125 |
| NCBI Synonym Full Names: | ring finger protein 125 |
| NCBI Official Symbol: | RNF125 |
| NCBI Official Synonym Symbols: | TNORS; TRAC1; TRAC-1 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase RNF125 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase RNF125 |
| UniProt Synonym Protein Names: | RING finger protein 125; T-cell RING activation protein 1 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | RNF125 |
| UniProt Entry Name: | RN125_HUMAN |
 | Immunofluorescence analysis of A549 cells using RNF125 antibody (CAB7982). Blue: DAPI for nuclear staining. |
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