Cell Biology Antibodies 18
Anti-RNF111 Antibody (CAB18277)
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- SKU:
- CAB18277
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RNF111 Antibody |
| Antibody SKU: | CAB18277 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human RNF111. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2, SGC-7901, HeLa |
| Immunogen: | Recombinant protein of human RNF111. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 54778 |
| Uniprot: | Q6ZNA4 |
| Cellular Location: | |
| Calculated MW: | 108kDa |
| Observed MW: | 120kDa |
 | Western blot - RNF111 Polyclonal Antibody (CAB18277) |
| Synonyms: | ARK, hRNF111, RNF111 |
| Background: | The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | RNF111: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligase; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 15q21 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus Molecular Function:protein binding; SUMO polymer binding Biological Process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; ubiquitin-dependent SMAD protein catabolic process |
| NCBI Summary: | The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q6ZNA4 |
| NCBI GenInfo Identifier: | 308153555 |
| NCBI Gene ID: | 54778 |
| NCBI Accession: | Q6ZNA4.3 |
| UniProt Secondary Accession: | Q6ZNA4,Q6P9A4, Q6ZMU2, Q7L428, Q7Z346, Q8N1P9, Q8WUA3 Q9NSR1, C9JUS4, H0YN55, |
| UniProt Related Accession: | Q6ZNA4 |
| Molecular Weight: | 108,906 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase Arkadia |
| NCBI Synonym Full Names: | ring finger protein 111 |
| NCBI Official Symbol: | RNF111 |
| NCBI Official Synonym Symbols: | ARK |
| NCBI Protein Information: | E3 ubiquitin-protein ligase Arkadia |
| UniProt Protein Name: | E3 ubiquitin-protein ligase Arkadia |
| UniProt Synonym Protein Names: | RING finger protein 111 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | RNF111 |
| UniProt Entry Name: | RN111_HUMAN |
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