Signal Transduction Antibodies 3
Anti-RNF11 Antibody (CAB8328)
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- SKU:
- CAB8328
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-RNF11 Antibody |
| Antibody SKU: | CAB8328 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human RNF11 (NP_055187.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human RNF11 (NP_055187.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGNC LKSP TSDD ISLL HESQ SDRA SFGE GTEP DQEP PPPY QEQV PVPV YHPT PSQT RLAT QLTE EEQI RIAQ RIGL IQHL PKGV YDPG RDGS EKKI RECV ICMM DFVY GDPI RFLP CMHI YHLD CIDD WLMR SFTC PSCM EPVD AALL SSYE TN |
| Gene ID: | 26994 |
| Uniprot: | Q9Y3C5 |
| Cellular Location: | Cytoplasm, Early endosome, Nucleus, Recycling endosome |
| Calculated MW: | 17kDa |
| Observed MW: | 27kDa |
| Synonyms: | RNF11, CGI-123, SID1669 |
| Background: | The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). |
| UniProt Protein Function: | RNF11: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Ubiquitin ligase Chromosomal Location of Human Ortholog: 1p32 Cellular Component: ubiquitin ligase complex Molecular Function:DNA binding; protein binding; ubiquitin-protein ligase activity Biological Process: protein autoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process |
| NCBI Summary: | The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3C5 |
| NCBI GenInfo Identifier: | 21362884 |
| NCBI Gene ID: | 26994 |
| NCBI Accession: | Q9Y3C5.1 |
| UniProt Secondary Accession: | Q9Y3C5,Q5T7R8, A8KAI2, |
| UniProt Related Accession: | Q9Y3C5 |
| Molecular Weight: | 17,444 Da |
| NCBI Full Name: | RING finger protein 11 |
| NCBI Synonym Full Names: | ring finger protein 11 |
| NCBI Official Symbol: | RNF11 |
| NCBI Official Synonym Symbols: | CGI-123; SID1669 |
| NCBI Protein Information: | RING finger protein 11 |
| UniProt Protein Name: | RING finger protein 11 |
| Protein Family: | RING finger protein |
| UniProt Gene Name: | RNF11 |
| UniProt Entry Name: | RNF11_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RNF11 antibody (CAB8328) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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