Cell Biology Antibodies 9
Anti-RNASEH2B Antibody (CAB4972)
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- SKU:
- CAB4972
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RNASEH2B
- Synonyms:
- AGS2
- Synonyms:
- DLEU8
- Research Area:
- Cell Biology
Description
| Product Name: | RNASEH2B Rabbit pAb |
| Product Code: | CAB4972 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | RNASEH2B, AGS2, DLEU8 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human RNASEH2B (NP_078846.2). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, Raji, K-562, HeLa, MCF-7, Mouse thymus, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human RNASEH2B (NP_078846.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAG VDCG DGVG ARQH VFLV SEYL KDAS KKMK NGLM FVKL VNPC SGEG AIYL FNMC LQQL FEVK VFKE KHHS WFIN QSVQ SGGL LHFA TPVD PLFL LLHY LIKA DKEG KFQP LDQV VVDN VFPN CILL LKLP GLEK LLHH VTEE KGNP EIDN KKYY KYSK EKTL KWLE KKVN QTVA ALKT NNVN VSSR VQST AFFS GDQA STDK EEDY IRYA HGLI SDYI PKEL SDDL SKYL KLPE PSAS LPNP PSKK IKLS DEPV EAKE DYTK FNTK DLKT EKKN SKMT AAQK ALAK VD |
| Gene ID: | 79621 |
| Uniprot: | Q5TBB1 |
| Cellular Location: | Nucleus |
| Calculated MW: | 29kDa/35kDa |
| Observed MW: | 37kDa |
| UniProt Protein Function: | RNASEH2B: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Belongs to the RNase H2 subunit B family. |
| UniProt Protein Details: | Protein type:DNA replication; RNA processing Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: nucleoplasm; nucleus Molecular Function:ribonuclease H activity Biological Process: positive regulation of fibroblast proliferation; ribonucleotide metabolic process; in utero embryonic development; RNA catabolic process; regulation of G2/M transition of mitotic cell cycle Disease: Aicardi-goutieres Syndrome 2 |
| NCBI Summary: | RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q5TBB1 |
| NCBI GenInfo Identifier: | 74745929 |
| NCBI Gene ID: | 79621 |
| NCBI Accession: | Q5TBB1.1 |
| UniProt Secondary Accession: | Q5TBB1,Q05DR2, Q6PK48, Q9HAF7, G3XAJ1, |
| UniProt Related Accession: | Q5TBB1 |
| Molecular Weight: | 312 |
| NCBI Full Name: | Ribonuclease H2 subunit B |
| NCBI Synonym Full Names: | ribonuclease H2, subunit B |
| NCBI Official Symbol: | RNASEH2B |
| NCBI Official Synonym Symbols: | AGS2; DLEU8 |
| NCBI Protein Information: | ribonuclease H2 subunit B; RNase H2 subunit B; ribonuclease HI subunit B; deleted in lymphocytic leukemia 8; Aicardi-Goutieres syndrome 2 protein |
| UniProt Protein Name: | Ribonuclease H2 subunit B |
| UniProt Synonym Protein Names: | Aicardi-Goutieres syndrome 2 protein; AGS2; Deleted in lymphocytic leukemia 8; Ribonuclease HI subunit B |
| Protein Family: | Ribonuclease |
| UniProt Gene Name: | RNASEH2B |
| UniProt Entry Name: | RNH2B_HUMAN |
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