Cell Biology Antibodies 9

Anti-RNASEH2B Antibody (CAB4972)

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SKU:
CAB4972

Description

Product Name:RNASEH2B Rabbit pAb
Product Code:CAB4972
Size:20uL, 50uL, 100uL
Synonyms:RNASEH2B, AGS2, DLEU8
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human RNASEH2B (NP_078846.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-431, Raji, K-562, HeLa, MCF-7, Mouse thymus, Rat thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human RNASEH2B (NP_078846.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAG VDCG DGVG ARQH VFLV SEYL KDAS KKMK NGLM FVKL VNPC SGEG AIYL FNMC LQQL FEVK VFKE KHHS WFIN QSVQ SGGL LHFA TPVD PLFL LLHY LIKA DKEG KFQP LDQV VVDN VFPN CILL LKLP GLEK LLHH VTEE KGNP EIDN KKYY KYSK EKTL KWLE KKVN QTVA ALKT NNVN VSSR VQST AFFS GDQA STDK EEDY IRYA HGLI SDYI PKEL SDDL SKYL KLPE PSAS LPNP PSKK IKLS DEPV EAKE DYTK FNTK DLKT EKKN SKMT AAQK ALAK VD
Gene ID:79621
Uniprot:Q5TBB1
Cellular Location:Nucleus
Calculated MW:29kDa/35kDa
Observed MW:37kDa
UniProt Protein Function:RNASEH2B: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Belongs to the RNase H2 subunit B family.
UniProt Protein Details:

Protein type:DNA replication; RNA processing

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: nucleoplasm; nucleus

Molecular Function:ribonuclease H activity

Biological Process: positive regulation of fibroblast proliferation; ribonucleotide metabolic process; in utero embryonic development; RNA catabolic process; regulation of G2/M transition of mitotic cell cycle

Disease: Aicardi-goutieres Syndrome 2

NCBI Summary:RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
UniProt Code:Q5TBB1
NCBI GenInfo Identifier:74745929
NCBI Gene ID:79621
NCBI Accession:Q5TBB1.1
UniProt Secondary Accession:Q5TBB1,Q05DR2, Q6PK48, Q9HAF7, G3XAJ1,
UniProt Related Accession:Q5TBB1
Molecular Weight:312
NCBI Full Name:Ribonuclease H2 subunit B
NCBI Synonym Full Names:ribonuclease H2, subunit B
NCBI Official Symbol:RNASEH2B  
NCBI Official Synonym Symbols:AGS2; DLEU8  
NCBI Protein Information:ribonuclease H2 subunit B; RNase H2 subunit B; ribonuclease HI subunit B; deleted in lymphocytic leukemia 8; Aicardi-Goutieres syndrome 2 protein
UniProt Protein Name:Ribonuclease H2 subunit B
UniProt Synonym Protein Names:Aicardi-Goutieres syndrome 2 protein; AGS2; Deleted in lymphocytic leukemia 8; Ribonuclease HI subunit B
Protein Family:Ribonuclease
UniProt Gene Name:RNASEH2B  
UniProt Entry Name:RNH2B_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RNASEH2B
Synonyms:
AGS2
Synonyms:
DLEU8
Research Area:
Cell Biology
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