Cell Biology Antibodies 7
Anti-RNASE3 Antibody (CAB1854)
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- SKU:
- CAB1854
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RNASE3 Antibody |
| Antibody SKU: | CAB1854 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-160 of human RNASE3 (NP_002926.2). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-160 of human RNASE3 (NP_002926.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RPPQ FTRA QWFA IQHI SLNP PRCT IAMR AINN YRWR CKNQ NTFL RTTF ANVV NVCG NQSI RCPH NRTL NNCH RSRF RVPL LHCD LINP GAQN ISNC TYAD RPGR RFYV VACD NRDP RDSP RYPV VPVH LDTT I |
| Gene ID: | 6037 |
| Uniprot: | P12724 |
| Cellular Location: | Secreted |
| Calculated MW: | 18kDa |
| Observed MW: |
| Synonyms: | RNASE3, ECP, RAF1, RNS3 |
| Background: | The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria |
| UniProt Protein Function: | RNASE3: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. Belongs to the pancreatic ribonuclease family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; EC 3.1.27.-; Ribonuclease Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: extracellular space; extracellular region Molecular Function:nucleic acid binding; endonuclease activity; ribonuclease activity Biological Process: defense response to Gram-positive bacterium; innate immune response in mucosa; RNA catabolic process; antibacterial humoral response |
| NCBI Summary: | The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014] |
| UniProt Code: | P12724 |
| NCBI GenInfo Identifier: | 147744558 |
| NCBI Gene ID: | 6037 |
| NCBI Accession: | P12724.2 |
| UniProt Secondary Accession: | P12724,Q4VBC1, Q8WTP7, Q8WZ62, Q9GZN9, |
| UniProt Related Accession: | P12724 |
| Molecular Weight: | 18kDa |
| NCBI Full Name: | Eosinophil cationic protein |
| NCBI Synonym Full Names: | ribonuclease, RNase A family, 3 |
| NCBI Official Symbol: | RNASE3 |
| NCBI Official Synonym Symbols: | ECP; RNS3 |
| NCBI Protein Information: | eosinophil cationic protein; RNase 3; ribonuclease 3; cytotoxic ribonuclease |
| UniProt Protein Name: | Eosinophil cationic protein |
| UniProt Synonym Protein Names: | Ribonuclease 3; RNase 3 |
| Protein Family: | Eosinophil cationic protein |
| UniProt Gene Name: | RNASE3 |
| UniProt Entry Name: | ECP_HUMAN |
 | Immunohistochemistry of paraffin-embedded human colon using RNASE3 antibody (CAB1854) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using RNASE3 antibody (CAB1854) at dilution of 1:100 (40x lens). |
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