Epigenetics & Nuclear Signaling Antibodies 4

Anti-RMI2 Antibody (CAB8523)

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SKU:
CAB8523
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-RMI2 Antibody
Antibody SKU:CAB8523
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human RMI2 (NP_689521.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human RMI2 (NP_689521.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAA ADSF SGGP AGVR LPRS PPLK VLAE QLRR DAEG GPGA WRLS RAAA GRGP LDLA AVWM QGRV VMAD RGEA RLRD PSGD FSVR GLER VPRG RPCL VPGK YVMV MGVV QACS PEPC LQAV KMTD LSDN PIHE SMWE LEVE DLHR NIP
Gene ID:116028
Uniprot:Q96E14
Cellular Location:Nucleus
Calculated MW:9kDa/15kDa
Observed MW:16kDa
Synonyms:RMI2, BLAP18, C16orf75
Background:
UniProt Protein Function:Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
NCBI Summary:RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008]
UniProt Code:Q96E14
NCBI GenInfo Identifier:24308245
NCBI Gene ID:116028
NCBI Accession:NP_689521.1
UniProt Secondary Accession:Q96E14,Q49AE2, Q8TBL0, B3KVZ6,
UniProt Related Accession:Q96E14
Molecular Weight:9,262 Da
NCBI Full Name:recQ-mediated genome instability protein 2
NCBI Synonym Full Names:RecQ mediated genome instability 2
NCBI Official Symbol:RMI2  
NCBI Official Synonym Symbols:BLAP18; C16orf75  
NCBI Protein Information:recQ-mediated genome instability protein 2
UniProt Protein Name:RecQ-mediated genome instability protein 2
UniProt Synonym Protein Names:BLM-associated protein of 18 kDa; BLAP18
Protein Family:RecQ-mediated genome instability protein
UniProt Gene Name:RMI2  
Anti-RMI2 Polyclonal Antibody (CAB8523)Western blot analysis of extracts of various cell lines, using RMI2 antibody (CAB8523) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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