Cell Biology Antibodies 6

Anti-RLN1 Antibody (CAB15714)

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SKU:
CAB15714
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RLN1 Antibody
Antibody SKU:CAB15714
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RLN1 (NP_008842.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:22Rv1
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RLN1 (NP_008842.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPRL FLFH LLEF CLLL NQFS RAVA AKWK DDVI KLCG RELV RAQI AICG MSTW SKRS LSQE DAPQ TPRP VAEI VPSF INKD TETI IIML EFIA NLPP ELKA
Gene ID:6013
Uniprot:P04808
Cellular Location:Secreted
Calculated MW:13kDa/21kDa
Observed MW:20kDa
Synonyms:RLN1, H1, H1RLX, RLXH1, bA12D24.3.1, bA12D24.3.2, relaxin 1
Background:Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin.
UniProt Protein Function:RLN1: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p24.1

NCBI Summary:Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]
UniProt Code:P04808
NCBI GenInfo Identifier:132280
NCBI Gene ID:6013
NCBI Accession:P04808.1
UniProt Secondary Accession:P04808,Q99936, Q9UQJ1,
UniProt Related Accession:P04808
Molecular Weight:13,011 Da
NCBI Full Name:Prorelaxin H1
NCBI Synonym Full Names:relaxin 1
NCBI Official Symbol:RLN1  
NCBI Official Synonym Symbols:H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2  
NCBI Protein Information:prorelaxin H1
UniProt Protein Name:Prorelaxin H1
Protein Family:Prorelaxin
UniProt Gene Name:RLN1  
UniProt Entry Name:REL1_HUMAN
Anti-RLN1 Antibody (CAB15714)Western blot analysis of extracts of 22Rv1 cells, using RLN1 antibody (CAB15714) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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