Anti-RING1A Antibody (CAB19750)
- SKU:
- CAB19750
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RING1A
- Synonyms:
- RNF1
Description
| Product Name: | RING1A Rabbit mAb |
| Product Code: | CAB19750 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | RING1A, RNF1 |
| Applications: | WB, IHC, IP |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human RING1A A |
| Applications: | WB, IHC, IP |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HeLa, HCT116 |
| Immunogen: | A synthesized peptide derived from human RING1A A |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6015 |
| Uniprot: | Q06587 |
| Calculated MW: | 50kDa |
| Observed MW: | 54KDa |
| UniProt Protein Function: | RING1: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. Component of chromatin-associated Polycomb (PcG) complexes. Interacts with BMI1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with PHC2. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligase; Transcription factor; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: nucleoplasm; sex chromatin; cytoplasm; nuclear speck; PcG protein complex; nucleus Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; chromatin binding; ligase activity Biological Process: anterior/posterior pattern formation; camera-type eye morphogenesis; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q06587 |
| NCBI GenInfo Identifier: | 90110053 |
| NCBI Gene ID: | 6015 |
| NCBI Accession: | Q06587.2 |
| UniProt Related Accession: | Q06587 |
| Molecular Weight: | Predicted Molecular Mass: 46.1kDaAccurate Molecular Mass: 43kDa |
| NCBI Full Name: | E3 ubiquitin-protein ligase RING1 |
| NCBI Synonym Full Names: | ring finger protein 1 |
| NCBI Official Symbol: | RING1 |
| NCBI Official Synonym Symbols: | RNF1; RING1A |
| NCBI Protein Information: | E3 ubiquitin-protein ligase RING1 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase RING1 |
| UniProt Synonym Protein Names: | Polycomb complex protein RING1; RING finger protein 1; Really interesting new gene 1 protein |
| Protein Family: | RING finger protein |
| UniProt Gene Name: | RING1 |
| UniProt Entry Name: | RING1_HUMAN |
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