Cell Biology Antibodies 4
Anti-RIN2 Antibody (CAB13798)
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- SKU:
- CAB13798
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RIN2 Antibody |
| Antibody SKU: | CAB13798 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 596-895 of human RIN2 (NP_061866.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, A-549, HeLa, HepG2, Mouse heart, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 596-895 of human RIN2 (NP_061866.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HKCI LKPL KGHV EAML KDFH MADG SWKQ LKEN LQLV RQRN PQEL GVFA PTPD FVDV EKIK VKFM TMQK MYSP EKKV MLLL RVCK LIYT VMEN NSGR MYGA DDFL PVLT YVIA QCDM LELD TEIE YMME LLDP SLLH GEGG YYLT SAYG ALSL IKNF QEEQ AARL LSSE TRDT LRQW HKRR TTNR TIPS VDDF QNYL RVAF QEVN SGCT GKTL LVRP YITT EDVC QICA EKFK VGDP EEYS LFLF VDET WQQL AEDT YPQK IKAE LHSR PQPH IFHF VYKR IKND PYGI IFQN GEED LTTS |
| Gene ID: | 54453 |
| Uniprot: | Q8WYP3 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 100kDa/105kDa |
| Observed MW: | 120kDa |
| Synonyms: | RIN2, MACS, RASSF4 |
| Background: | The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. |
| NCBI Summary: | The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011] |
| UniProt Code: | Q8WYP3 |
| NCBI GenInfo Identifier: | 18466802 |
| NCBI Gene ID: | 54453 |
| NCBI Accession: | NP_061866 |
| UniProt Related Accession: | Q8WYP3 |
| Molecular Weight: | |
| NCBI Full Name: | ras and Rab interactor 2 isoform 2 |
| NCBI Synonym Full Names: | Ras and Rab interactor 2 |
| NCBI Official Symbol: | RIN2 |
| NCBI Official Synonym Symbols: | MACS; RASSF4 |
| NCBI Protein Information: | ras and Rab interactor 2 |
| UniProt Protein Name: | Ras and Rab interactor 2 |
| UniProt Synonym Protein Names: | Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2 |
| Protein Family: | Ras and Rab interactor |
| UniProt Gene Name: | RIN2 |
| UniProt Entry Name: | RIN2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RIN2 antibody (CAB13798) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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