Cell Biology Antibodies 8

Anti-RHOT2 Antibody (CAB2597)

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SKU:
CAB2597
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RHOT2 Antibody
Antibody SKU:CAB2597
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-480 of human RHOT2 (NP_620124.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 280-480 of human RHOT2 (NP_620124.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LELT ADYL SPLI HVPP GCST ELNH LGYQ FVQR VFEK HDQD RDGA LSPV ELQS LFSV FPAA PWGP ELPR TVRT EAGR LPLH GYLC QWTL VTYL DVRS CLGH LGYL GYPT LCEQ DQAH AITV TREK RLDQ EKGQ TQRS VLLC KVVG ARGV GKSA FLQA FLGR GLGH QDTR EQPP GYAI DTVQ VNGQ EKYL ILCE VGTD GLLA T
Gene ID:89941
Uniprot:Q8IXI1
Cellular Location:Mitochondrion outer membrane, Single-pass type IV membrane protein
Calculated MW:23kDa/68kDa
Observed MW:68kDa
Synonyms:RHOT2, ARHT2, C16orf39, MIRO-2, MIRO2, RASL
Background:This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics.
UniProt Protein Function:RHOT2: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Belongs to the mitochondrial Rho GTPase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Hydrolase; G protein, monomeric, Rho; Membrane protein, integral; G protein, monomeric; EC 3.6.5.-; Mitochondrial; G protein

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: membrane; plasma membrane; cytosol; integral to mitochondrial outer membrane

Molecular Function:GTPase activity; protein binding; GTP binding; calcium ion binding

Biological Process: regulation of small GTPase mediated signal transduction; metabolic process; small GTPase mediated signal transduction; cellular homeostasis; mitochondrion transport along microtubule

NCBI Summary:This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
UniProt Code:Q8IXI1
NCBI GenInfo Identifier:108860798
NCBI Gene ID:89941
NCBI Accession:Q8IXI1.2
UniProt Secondary Accession:Q8IXI1,Q8NF53, Q96C13, Q96S17, Q9BT60, Q9H7M8, A2IDC2
UniProt Related Accession:Q8IXI1
Molecular Weight:Observed MW 68kDaCalculated MW 23kDa/68kDa
NCBI Full Name:Mitochondrial Rho GTPase 2
NCBI Synonym Full Names:ras homolog family member T2
NCBI Official Symbol:RHOT2  
NCBI Official Synonym Symbols:RASL; ARHT2; MIRO2; MIRO-2; C16orf39  
NCBI Protein Information:mitochondrial Rho GTPase 2; mitochondrial Rho (MIRO) GTPase 2; ras homolog gene family, member T2
UniProt Protein Name:Mitochondrial Rho GTPase 2
UniProt Synonym Protein Names:Ras homolog gene family member T2
UniProt Gene Name:RHOT2  
UniProt Entry Name:MIRO2_HUMAN
Anti-RHOT2 Antibody (CAB2597)Western blot analysis of extracts of rat liver, using RHOT2 antibody (CAB2597) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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