Cardiovascular Antibodies
Anti-RHOB Antibody (CAB2819)
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- SKU:
- CAB2819
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-RHOB Antibody |
| Antibody SKU: | CAB2819 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RHOB (NP_004031.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RHOB (NP_004031.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VPEV KHFC PNVP IILV ANKK DLRS DEHV RTEL ARMK QEPV RTDD GRAM AVRI QAYD YLEC SAKT KEGV REVF ETAT RAAL QKRY GSQN GCIN CCKV L |
| Gene ID: | 388 |
| Uniprot: | P62745 |
| Cellular Location: | Cell membrane, Cleavage furrow, Late endosome membrane, Lipid-anchor, Nucleus |
| Calculated MW: | 22kDa |
| Observed MW: | 22kDa |
| Synonyms: | RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 |
| Background: |
| UniProt Protein Function: | RHOB: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Tumor suppressor Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: cleavage furrow; cytosol; endosome membrane; focal adhesion; nucleus; plasma membrane Molecular Function:GTP binding; GTPase activity; protein binding Biological Process: apoptosis; cell adhesion; cytokinesis; endosome to lysosome transport; negative regulation of cell cycle; negative regulation of cell migration; platelet activation; positive regulation of angiogenesis; positive regulation of apoptosis; regulation of cell migration; regulation of small GTPase mediated signal transduction; Rho protein signal transduction |
| UniProt Code: | P62745 |
| NCBI GenInfo Identifier: | 51338601 |
| NCBI Gene ID: | 388 |
| NCBI Accession: | P62745.1 |
| UniProt Secondary Accession: | P62745,P01121, Q5U0H6, Q7RTN5, Q7RTR9, Q9CUV7, B2R692 |
| UniProt Related Accession: | P62745 |
| Molecular Weight: | 22kDa |
| NCBI Full Name: | Rho-related GTP-binding protein RhoB |
| NCBI Synonym Full Names: | ras homolog family member B |
| NCBI Official Symbol: | RHOB |
| NCBI Official Synonym Symbols: | ARH6; ARHB; RHOH6; MST081; MSTP081 |
| NCBI Protein Information: | rho-related GTP-binding protein RhoB |
| UniProt Protein Name: | Rho-related GTP-binding protein RhoB |
| UniProt Synonym Protein Names: | Rho cDNA clone 6; h6 |
| Protein Family: | Rho-related GTP-binding protein |
| UniProt Gene Name: | RHOB |
 | Western blot analysis of extracts of mouse brain, using RHOB Antibody (CAB2819) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using RHOB antibody (CAB2819) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using RHOB antibody (CAB2819) at dilution of 1:100 (40x lens). |
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