Cardiovascular Antibodies
Anti-RHOB Antibody (CAB12402)
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- SKU:
- CAB12402
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-RHOB Antibody |
| Antibody SKU: | CAB12402 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-196 of human RHOB (NP_004031.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-196 of human RHOB (NP_004031.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAI RKKL VVVG DGAC GKTC LLIV FSKD EFPE VYVP TVFE NYVA DIEV DGKQ VELA LWDT AGQE DYDR LRPL SYPD TDVI LMCF SVDS PDSL ENIP EKWV PEVK HFCP NVPI ILVA NKKD LRSD EHVR TELA RMKQ EPVR TDDG RAMA VRIQ AYDY LECS AKTK EGVR EVFE TATR AALQ KRYG SQNG CINC CKVL |
| Gene ID: | 388 |
| Uniprot: | P62745 |
| Cellular Location: | Cell membrane, Cleavage furrow, Late endosome membrane, Lipid-anchor, Nucleus |
| Calculated MW: | 22kDa |
| Observed MW: | 22kDa |
| Synonyms: | RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 |
| Background: |
| UniProt Protein Function: | RHOB: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Tumor suppressor Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: cleavage furrow; cytosol; endosome membrane; focal adhesion; nucleus; plasma membrane Molecular Function:GTP binding; GTPase activity; protein binding Biological Process: apoptosis; cell adhesion; cytokinesis; endosome to lysosome transport; negative regulation of cell cycle; negative regulation of cell migration; platelet activation; positive regulation of angiogenesis; positive regulation of apoptosis; regulation of cell migration; regulation of small GTPase mediated signal transduction; Rho protein signal transduction |
| UniProt Code: | P62745 |
| NCBI GenInfo Identifier: | 51338601 |
| NCBI Gene ID: | 388 |
| NCBI Accession: | P62745.1 |
| UniProt Secondary Accession: | P62745,P01121, Q5U0H6, Q7RTN5, Q7RTR9, Q9CUV7, B2R692 |
| UniProt Related Accession: | P62745 |
| Molecular Weight: | 22kDa |
| NCBI Full Name: | Rho-related GTP-binding protein RhoB |
| NCBI Synonym Full Names: | ras homolog family member B |
| NCBI Official Symbol: | RHOB |
| NCBI Official Synonym Symbols: | ARH6; ARHB; RHOH6; MST081; MSTP081 |
| NCBI Protein Information: | rho-related GTP-binding protein RhoB |
| UniProt Protein Name: | Rho-related GTP-binding protein RhoB |
| UniProt Synonym Protein Names: | Rho cDNA clone 6; h6 |
| Protein Family: | Rho-related GTP-binding protein |
| UniProt Gene Name: | RHOB |
 | Western blot analysis of extracts of various cell lines, using RHOB antibody (CAB12402) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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