Anti-RhoA [KO Validated] Antibody (CAB18695)

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SKU:
CAB18695
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ARHA
Synonyms:
ARH12
Synonyms:
RHO12
Synonyms:
EDFAOB
Synonyms:
RHOH12
Research Area:
Cell Cycle

Description

Product Name:[KO Validated] RhoA Rabbit pAb
Product Code:CAB18695
Size:20uL
Synonyms:ARHA, ARH12, RHO12, EDFAOB, RHOH12
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human RhoA.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, NIH/3T3, U-251MG, HUVEC, Mouse brain
Immunogen:Recombinant protein of human RhoA.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:387
Uniprot:P61586
Cellular Location:Cell membrane, Cell projection, Cleavage furrow, Cytoplasm, Cytoplasmic side, Lipid-anchor, Midbody, cell cortex, cytoskeleton, lamellipodium
Calculated MW:21kDa
Observed MW:21kDa
UniProt Protein Function:RHOA: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.
UniProt Protein Details:

Protein type:G protein, monomeric, Rho; G protein, monomeric; Motility/polarity/chemotaxis; Oncoprotein; G protein

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: apical junction complex; focal adhesion; cytoskeleton; lamellipodium; plasma membrane; cell cortex; midbody; cytosol; cell junction; cleavage furrow

Molecular Function:GTPase activity; protein binding; myosin binding; GTP binding

Biological Process: axon guidance; nerve growth factor receptor signaling pathway; viral reproduction; metabolic process; negative chemotaxis; positive regulation of NF-kappaB import into nucleus; regulation of axonogenesis; regulation of cell migration; Rho protein signal transduction; regulation of osteoblast proliferation; substantia nigra development; transforming growth factor beta receptor signaling pathway; small GTPase mediated signal transduction; positive regulation of stress fiber formation; ephrin receptor signaling pathway; negative regulation of axonogenesis; positive regulation of cytokinesis; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; phosphoinositide-mediated signaling; apical junction assembly; regulation of small GTPase mediated signal transduction; positive regulation of axonogenesis; actin cytoskeleton organization and biogenesis; positive regulation of neuron differentiation; vascular endothelial growth factor receptor signaling pathway; blood coagulation

NCBI Summary:This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
UniProt Code:P61586
NCBI GenInfo Identifier:47606458
NCBI Gene ID:387
NCBI Accession:P61586.1
UniProt Related Accession:P61586
Molecular Weight:22kDa
NCBI Full Name:Transforming protein RhoA
NCBI Synonym Full Names:ras homolog family member A
NCBI Official Symbol:RHOA  
NCBI Official Synonym Symbols:ARHA; ARH12; RHO12; RHOH12  
NCBI Protein Information:transforming protein RhoA
UniProt Protein Name:Transforming protein RhoA
UniProt Synonym Protein Names:Rho cDNA clone 12; h12
Protein Family:Rhotekin
UniProt Gene Name:RHOA  
UniProt Entry Name:RHOA_HUMAN
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