Cell Biology Antibodies 5
Anti-RHBDL2 Antibody (CAB14407)
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- SKU:
- CAB14407
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RHBDL2 Antibody |
| Antibody SKU: | CAB14407 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 12-130 of human RHBDL2 (NP_060291.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse stomach, Rat uterus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 12-130 of human RHBDL2 (NP_060291.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNLN MGRE MKEE LEEE EKMR EDGG GKDR AKSK KVHR IVSK WMLP EKSR GTYL ERAN CFPP PVFI ISIS LAEL AVFI YYAV WKPQ KQWI TLDT GILE SPFI YSPE KREE AWRF ISYM LVH |
| Gene ID: | 54933 |
| Uniprot: | Q9NX52 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 15kDa/34kDa |
| Observed MW: | 34kDa |
| Synonyms: | RHBDL2, RRP2 |
| Background: | The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | RHBDL2: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3. Belongs to the peptidase S54 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Protease Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: integral to membrane; plasma membrane Molecular Function:serine-type endopeptidase activity Biological Process: protein processing |
| NCBI Summary: | The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015] |
| UniProt Code: | Q9NX52 |
| NCBI GenInfo Identifier: | 54144654 |
| NCBI Gene ID: | 54933 |
| NCBI Accession: | NP_060291.2 |
| UniProt Secondary Accession: | Q9NX52,Q6P175, Q8NER8, Q96E02, B2RNT3, B9EH75, |
| UniProt Related Accession: | Q9NX52 |
| Molecular Weight: | 18.3kD |
| NCBI Full Name: | rhomboid-related protein 2 isoform 2 |
| NCBI Synonym Full Names: | rhomboid like 2 |
| NCBI Official Symbol: | RHBDL2 |
| NCBI Official Synonym Symbols: | RRP2 |
| NCBI Protein Information: | rhomboid-related protein 2 |
| UniProt Protein Name: | Rhomboid-related protein 2 |
| UniProt Synonym Protein Names: | Rhomboid-like protein 2 |
| Protein Family: | Rhomboid-related protein |
| UniProt Gene Name: | RHBDL2 |
 | Western blot analysis of extracts of various cell lines, using RHBDL2 antibody (CAB14407) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 40s. |
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