Cell Biology Antibodies 6

Anti-RHBDL1 Antibody (CAB16084)

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SKU:
CAB16084
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RHBDL1 Antibody
Antibody SKU:CAB16084
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human RHBDL1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Mouse kidney, Mouse testis, Rat brain, Rat kidney
Immunogen:Recombinant protein of human RHBDL1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9028
Uniprot:O75783
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:41kDa/48kDa
Observed MW:48kDa
Synonyms:RHBDL1, RHBDL, RRP
Background:This gene encodes a protein similar to Rhomboid in Drosophila which is involved in signalling in the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. The Rhomboid family of proteins consists of intramembrane serine proteases containing several transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:RHBDL1: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Belongs to the peptidase S54 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; EC 3.4.21.105; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: integral to plasma membrane; membrane; mitochondrial inner membrane

Molecular Function:serine-type endopeptidase activity

Biological Process: protein processing; signal transduction

NCBI Summary:This gene encodes a protein similar to Rhomboid in Drosophila which is involved in signalling in the Spitz/epidermal growth factor receptor/mitogen-activated protein kinase pathway. The Rhomboid family of proteins consists of intramembrane serine proteases containing several transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
UniProt Code:O75783
NCBI GenInfo Identifier:20139374
NCBI Gene ID:9028
NCBI Accession:O75783.1
UniProt Secondary Accession:O75783,Q0VAX4, Q9NQ85, A2IDC0, A2IDC1,
UniProt Related Accession:O75783
Molecular Weight:41,720 Da
NCBI Full Name:Rhomboid-related protein 1
NCBI Synonym Full Names:rhomboid like 1
NCBI Official Symbol:RHBDL1  
NCBI Official Synonym Symbols:RRP; RHBDL  
NCBI Protein Information:rhomboid-related protein 1
UniProt Protein Name:Rhomboid-related protein 1
UniProt Synonym Protein Names:Rhomboid-like protein 1
UniProt Gene Name:RHBDL1  
UniProt Entry Name:RHBL1_HUMAN
Anti-RHBDL1 Antibody (CAB16084)Western blot analysis of extracts of various cell lines, using RHBDL1 antibody (CAB16084) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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