Cell Death Antibodies 1
Anti-RHBDD1 Antibody (CAB14350)
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- SKU:
- CAB14350
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-RHBDD1 Antibody |
| Antibody SKU: | CAB14350 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 206-315 of human RHBDD1 (NP_115652.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, BxPC-3, Raji, mouse brain, mouse kidney, rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 206-315 of human RHBDD1 (NP_115652.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TQGP LKKI MEAC AGGF SSSV GYPG RQYY FNSS GSSG YQDY YPHG RPDH YEEA PRNY DTYT AGLS EEEQ LERA LQAS LWDR GNTR NSPP PYGF HLSP EEMR RQRL HRFD SQ |
| Gene ID: | 84236 |
| Uniprot: | Q8TEB9 |
| Cellular Location: | Endoplasmic reticulum membrane, Membrane, Mitochondrion, Multi-pass membrane protein |
| Calculated MW: | 12kDa/35kDa |
| Observed MW: | 35kDa |
| Synonyms: | RHBDD1, RRP4 |
| Background: |
| UniProt Protein Function: | RHBDD1: Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia. Belongs to the peptidase S54 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Protease Chromosomal Location of Human Ortholog: 2q36.3 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane Biological Process: membrane protein intracellular domain proteolysis; negative regulation of apoptosis; post-translational protein modification; spermatid differentiation |
| UniProt Code: | Q8TEB9 |
| NCBI GenInfo Identifier: | 83405869 |
| NCBI Gene ID: | 84236 |
| NCBI Accession: | |
| UniProt Secondary Accession: | Q8TEB9,Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q9H057 |
| UniProt Related Accession: | Q8TEB9 |
| Molecular Weight: | 12,346 Da |
| NCBI Full Name: | Rhomboid domain containing 1 |
| NCBI Synonym Full Names: | rhomboid domain containing 1 |
| NCBI Official Symbol: | RHBDD1 |
| NCBI Official Synonym Symbols: | RRP4 |
| NCBI Protein Information: | rhomboid-related protein 4 |
| UniProt Protein Name: | Rhomboid-related protein 4 |
| UniProt Synonym Protein Names: | Rhomboid domain-containing protein 1; Rhomboid-like protein 4 |
| UniProt Gene Name: | RHBDD1 |
| UniProt Entry Name: | RHBL4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RHBDD1 antibody (CAB14350) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of L929 cells using RHBDD1 Polyclonal Antibody (CAB14350) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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