Signal Transduction Antibodies 3
Anti-RGS9 Antibody (CAB9326)
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- SKU:
- CAB9326
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-RGS9 Antibody |
| Antibody SKU: | CAB9326 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-350 of human RGS9 (NP_003826.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-350 of human RGS9 (NP_003826.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MYYQ QALM RSTV KSSV SLGG IVKY SEQF SSND AIMS GCLP SNPW ITDD TQFW DLNA KLVE IPTK MRVE RWAF NFSE LIRD PKGR QSFQ YFLK KEFS GENL GFWE ACED LKYG DQSK VKEK A |
| Gene ID: | 8787 |
| Uniprot: | O75916 |
| Cellular Location: | Membrane, Peripheral membrane protein |
| Calculated MW: | 49kDa/54kDa/56kDa/76kDa |
| Observed MW: | 77kDa |
| Synonyms: | RGS9, PERRS, RGS9L |
| Background: | This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | RGS9: belongs to the 'regulator of G protein signaling' family. Inhibits signal transduction by increasing the GTPAse activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction. Four alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 17q24 Cellular Component: cytoplasm; plasma membrane; heterotrimeric G-protein complex; nucleus Molecular Function:signal transducer activity; protein complex binding; GTPase activator activity Biological Process: rhodopsin mediated signaling; phototransduction, visible light; nervous system development; regulation of rhodopsin mediated signaling; visual perception; response to estrogen stimulus; dopamine receptor signaling pathway; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity Disease: Prolonged Electroretinal Response Suppression |
| NCBI Summary: | This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | O75916 |
| NCBI GenInfo Identifier: | 8475983 |
| NCBI Gene ID: | 8787 |
| NCBI Accession: | O75916.1 |
| UniProt Related Accession: | O75916 |
| Molecular Weight: | 49kDa; 54kDa; 56kDa; 76kDa |
| NCBI Full Name: | Regulator of G-protein signaling 9 |
| NCBI Synonym Full Names: | regulator of G protein signaling 9 |
| NCBI Official Symbol: | RGS9 |
| NCBI Official Synonym Symbols: | PERRS; RGS9L |
| NCBI Protein Information: | regulator of G-protein signaling 9 |
| UniProt Protein Name: | Regulator of G-protein signaling 9 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS9 |
| UniProt Entry Name: | RGS9_HUMAN |
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