Cell Biology Antibodies 10

Anti-RGS7 Antibody (CAB6720)

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SKU:
CAB6720
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RGS7 Antibody
Antibody SKU:CAB6720
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RGS7 (NP_002915.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RGS7 (NP_002915.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAQG NNYG QTSN GVAD ESPN MLVY RKME DVIA RMQD EKNG IPIR TVKS FLSK IPSV FSGS DIVQ WLIK NLTI EDPV EALH LGTL MAAH GYFF PISD HVLT LKDD GTFY RFQT PYFW PSNC WEPE NTDY AVYL CKRT MQNK ARLE LADY EAES LARL QRAF ARKW EFIF MQAE AQAK VDKK RDKI ERKI LDSQ ERAF WDVH RPVP GCVN TTEV DIKK SSRM RNPH KTRK SVYG LQND IRSH SPTH TPTP ETKP PTED ELQQ QIKY WQIQ LDRH RLKM SKVA DSLL SYTE QYLE YDPF LLPP
Gene ID:6000
Uniprot:P49802
Cellular Location:
Calculated MW:49kDa/54kDa/55kDa/56kDa/57kDa
Observed MW:58kDa
Synonyms:RGS7
Background:
UniProt Protein Function:RGS7: inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP. Four alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 1q43|1q23.1

Cellular Component: cytoplasm; plasma membrane; heterotrimeric G-protein complex; cytosol; nucleus

Molecular Function:signal transducer activity; G-protein beta-subunit binding; GTPase activator activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity

UniProt Code:P49802
NCBI GenInfo Identifier:17380284
NCBI Gene ID:6000
NCBI Accession:P49802.3
UniProt Secondary Accession:P49802,Q5T3H4, Q8TD66, Q8TD67, Q8WW09, Q9UNU7, Q9Y6B9
UniProt Related Accession:P49802
Molecular Weight:495
NCBI Full Name:Regulator of G-protein signaling 7
NCBI Synonym Full Names:regulator of G-protein signaling 7
NCBI Official Symbol:RGS7  
NCBI Protein Information:regulator of G-protein signaling 7; regulator of G-protein signalling 7; regulator of G-protein signaling RGS7
UniProt Protein Name:Regulator of G-protein signaling 7
Protein Family:Regulator of G-protein signaling
UniProt Gene Name:RGS7  
UniProt Entry Name:RGS7_HUMAN
Anti-RGS7 Antibody (CAB6720)Western blot analysis of extracts of mouse brain, using RGS7 antibody (CAB6720) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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