Name: Anti-RGS6 Antibody (CAB18407)
Brand: Cell Biology Antibodies 18
SKU: CAB18407
Availability: OutOfStock

Antibody Name:	Anti-RGS6 Antibody
Antibody SKU:	CAB18407
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant protein of human RGS6.

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:

Immunogen:	Recombinant protein of human RGS6.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	9628
Uniprot:	P49758
Cellular Location:
Calculated MW:
Observed MW:	Refer to figures

Synonyms:	GAP, HA117, S914, RGS6
Background:

UniProt Protein Function:	RGS6: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer. 11 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: Golgi apparatus; cytoplasm; plasma membrane; heterotrimeric G-protein complex Molecular Function:protein domain specific binding; protein binding; signal transducer activity; GTPase activator activity Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of neuron differentiation; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
NCBI Summary:	This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
UniProt Code:	P49758
NCBI GenInfo Identifier:	325053674
NCBI Gene ID:	9628
NCBI Accession:	NP_001191345.1
UniProt Secondary Accession:	P49758,O75576, O75577, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6 Q8TE13, Q8TE14, Q8TE15, C9JE95, F8W7W5,
UniProt Related Accession:	P49758
Molecular Weight:	54,423 Da
NCBI Full Name:	regulator of G-protein signaling 6 isoform 1
NCBI Synonym Full Names:	regulator of G-protein signaling 6
NCBI Official Symbol:	RGS6
NCBI Official Synonym Symbols:	GAP
NCBI Protein Information:	regulator of G-protein signaling 6; S914; H_DJ1108A12.1; WUGSC:H_DJ0283M22.1; WUGSC:H_DJ1108A12.1; GTPase activating protein; regulator of G-protein signalling 6
UniProt Protein Name:	Regulator of G-protein signaling 6
UniProt Synonym Protein Names:	S914
Protein Family:	Regulator of G-protein signaling
UniProt Gene Name:	RGS6
UniProt Entry Name:	RGS6_HUMAN