Cell Biology Antibodies 18

Anti-RGS6 Antibody (CAB18407)

(No reviews yet) Write a Review
SKU:
CAB18407
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-RGS6 Antibody
Antibody SKU:CAB18407
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human RGS6.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:Recombinant protein of human RGS6.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9628
Uniprot:P49758
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:GAP, HA117, S914, RGS6
Background:
UniProt Protein Function:RGS6: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer. 11 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: Golgi apparatus; cytoplasm; plasma membrane; heterotrimeric G-protein complex

Molecular Function:protein domain specific binding; protein binding; signal transducer activity; GTPase activator activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of neuron differentiation; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity

NCBI Summary:This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
UniProt Code:P49758
NCBI GenInfo Identifier:325053674
NCBI Gene ID:9628
NCBI Accession:NP_001191345.1
UniProt Secondary Accession:P49758,O75576, O75577, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6 Q8TE13, Q8TE14, Q8TE15, C9JE95, F8W7W5,
UniProt Related Accession:P49758
Molecular Weight:54,423 Da
NCBI Full Name:regulator of G-protein signaling 6 isoform 1
NCBI Synonym Full Names:regulator of G-protein signaling 6
NCBI Official Symbol:RGS6  
NCBI Official Synonym Symbols:GAP  
NCBI Protein Information:regulator of G-protein signaling 6; S914; H_DJ1108A12.1; WUGSC:H_DJ0283M22.1; WUGSC:H_DJ1108A12.1; GTPase activating protein; regulator of G-protein signalling 6
UniProt Protein Name:Regulator of G-protein signaling 6
UniProt Synonym Protein Names:S914
Protein Family:Regulator of G-protein signaling
UniProt Gene Name:RGS6  
UniProt Entry Name:RGS6_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products