Cell Biology Antibodies 10
Anti-RGS5 Antibody (CAB7015)
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- SKU:
- CAB7015
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RGS5 Antibody |
| Antibody SKU: | CAB7015 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human RGS5 (NP_003608.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human RGS5 (NP_003608.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MCKG LAAL PHSC LERA KEIK IKLG ILLQ KPDS VGDL VIPY NEKP EKPA KTQK TSLD EALQ WRDS LDKL LQNN YGLA SFKS FLKS EFSE ENLE FWIA CEDY KKIK SPAK MAEK AKQI YEEF IQTE APKE VNID HFTK DITM KNLV EPSL SSFD MAQK RIHA LMEK DSLP RFVR SEFY QELI K |
| Gene ID: | 8490 |
| Uniprot: | O15539 |
| Cellular Location: | Cytoplasm, Membrane |
| Calculated MW: | 8kDa/20kDa/21kDa |
| Observed MW: | 50kDa |
| Synonyms: | RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129 |
| Background: | This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. |
| UniProt Protein Function: | RGS5: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: cytoplasm; plasma membrane Molecular Function:GTPase activator activity Biological Process: regulation of G-protein coupled receptor protein signaling pathway Disease: Hypertension, Essential |
| NCBI Summary: | This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011] |
| UniProt Code: | O15539 |
| NCBI GenInfo Identifier: | 3914625 |
| NCBI Gene ID: | 8490 |
| NCBI Accession: | O15539.1 |
| UniProt Secondary Accession: | O15539,Q53XA9, Q599J0, E9PMP5, |
| UniProt Related Accession: | O15539 |
| Molecular Weight: | 21,402 Da |
| NCBI Full Name: | Regulator of G-protein signaling 5 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 5 |
| NCBI Official Symbol: | RGS5 |
| NCBI Official Synonym Symbols: | MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129 |
| NCBI Protein Information: | regulator of G-protein signaling 5 |
| UniProt Protein Name: | Regulator of G-protein signaling 5 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS5 |
| UniProt Entry Name: | RGS5_HUMAN |
 | Western blot analysis of extracts of Mouse heart, using RGS5 Rabbit pAb (CAB7015) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver using RGS5 antibody (CAB7015) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat lung using RGS5 antibody (CAB7015) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using RGS5 antibody (CAB7015) at dilution of 1:100 (40x lens). |
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