Cell Biology Antibodies 6

Anti-RGS17 Antibody (CAB15815)

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SKU:
CAB15815
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RGS17 Antibody
Antibody SKU:CAB15815
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-130 of human RGS17 (NP_036551.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-130 of human RGS17 (NP_036551.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NEER GENA GRPT HTTK MESI QVLE ECQN PTAE EVLS WSQN FDKM MKAP AGRN LFRE FLRT EYSE ENLL FWLA CEDL KKEQ NKKV IE
Gene ID:26575
Uniprot:Q9UGC6
Cellular Location:Cytoplasm, Lipid-anchor, Membrane, Nucleus
Calculated MW:24kDa
Observed MW:24kDa
Synonyms:RGS17, RGS-17, RGSZ2, hRGS17
Background:This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
UniProt Protein Function:RGS17: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
UniProt Protein Details:

Protein type:GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: cytoplasm; plasma membrane; nucleus

Molecular Function:GTPase activator activity

Biological Process: positive regulation of GTPase activity

NCBI Summary:This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UGC6
NCBI GenInfo Identifier:21361405
NCBI Gene ID:26575
NCBI Accession:NP_036551
UniProt Secondary Accession:Q9UGC6,Q5TF49, Q8TD61, Q9UJS8,
UniProt Related Accession:Q9UGC6
Molecular Weight:24,359 Da
NCBI Full Name:regulator of G-protein signaling 17
NCBI Synonym Full Names:regulator of G-protein signaling 17
NCBI Official Symbol:RGS17  
NCBI Official Synonym Symbols:RGSZ2; RGS-17; hRGS17  
NCBI Protein Information:regulator of G-protein signaling 17
UniProt Protein Name:Regulator of G-protein signaling 17
Protein Family:Regulator of G-protein signaling
UniProt Gene Name:RGS17  
UniProt Entry Name:RGS17_HUMAN
Anti-RGS17 Antibody (CAB15815)Western blot analysis of extracts of various cell lines, using RGS17 antibody (CAB15815) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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