Cell Biology Antibodies 8
Anti-RGN Antibody (CAB3350)
(No reviews yet)
Write a Review
- SKU:
- CAB3350
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RGN Antibody |
| Antibody SKU: | CAB3350 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human RGN (NP_004674.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Rat kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human RGN (NP_004674.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSI KIEC VLPE NCRC GESP VWEE VSNS LLFV DIPA KKVC RWDS FTKQ VQRV TMDA PVSS VALR QSGG YVAT IGTK FCAL NWKE QSAV VLAT VDND KKNN RFND GKVD PAGR YFAG TMAE ETAP AVLE RHQG ALYS LFPD HHVK KYFD QVDI SNGL DWSL DHKI FYYI DSLS YSVD AFDY DLQT GQIS NRRS VYKL EKEE QIPD GMCI DAEG KLWV ACYN GGRV IRLD PVTG KRLQ TVKL PVDK TTSC CFGG KNYS EMYV TCAR DGMD PEGL LRQP EAGG IFKI TGLG VKGI APYS YAG |
| Gene ID: | 9104 |
| Uniprot: | Q15493 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 24kDa/33kDa |
| Observed MW: | 35kDa |
| Synonyms: | RGN, GNL, HEL-S-41, RC, SMP30 |
| Background: | The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | RGN: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities. Belongs to the SMP-30/CGR1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.1.17 Chromosomal Location of Human Ortholog: Xp11.3 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:zinc ion binding; gluconolactonase activity; calcium ion binding; enzyme regulator activity Biological Process: cellular calcium ion homeostasis; L-ascorbic acid biosynthetic process; positive regulation of ATPase activity; regulation of calcium-mediated signaling |
| NCBI Summary: | The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q15493 |
| NCBI GenInfo Identifier: | 3334328 |
| NCBI Gene ID: | 9104 |
| NCBI Accession: | Q15493.1 |
| UniProt Related Accession: | Q15493 |
| Molecular Weight: | 33 kDa |
| NCBI Full Name: | Regucalcin |
| NCBI Synonym Full Names: | regucalcin |
| NCBI Official Symbol: | RGN |
| NCBI Official Synonym Symbols: | RC; GNL; SMP30; HEL-S-41 |
| NCBI Protein Information: | regucalcin |
| UniProt Protein Name: | Regucalcin |
| UniProt Synonym Protein Names: | Gluconolactonase (EC:3.1.1.17); GNL; Senescence marker protein 30; SMP-30 |
| Protein Family: | Regucalcin |
| UniProt Gene Name: | RGN |
| UniProt Entry Name: | RGN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RGN antibody (CAB3350) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
View AllClose
Related Products
