Cell Biology Antibodies 3

Anti-RGMB Antibody (CAB12859)

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SKU:
CAB12859
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RGMB Antibody
Antibody SKU:CAB12859
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-453 of human RGMB (NP_001012779.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-453 of human RGMB (NP_001012779.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PHLR TFKD NFQT CKVE GAWP LIDN NYLS VQVT NVPV VPGS SATA TNKI TIIF KAHH ECTD QKVY QAVT DDLP AAFV DGTT SGGD SDAK SLRI VERE SGHY VEMH ARYI GTTV FVRQ VGRY LTLA IRMP EDLA MSYE ESQD LQLC VNGC PLSE RIDD GQGQ VSAI LGHS LPRT SLVQ AWPG YTLE TANT QCHE KMPV KDIY FQSC VFDL LTTG DANF TAAA HSAL EDVE ALHP RKER WHIF PSSG
Gene ID:285704
Uniprot:Q6NW40
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor, Membrane raft
Calculated MW:47kDa
Observed MW:47kDa
Synonyms:RGMB, DRAGON
Background:
UniProt Protein Function:RGMB: Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth. Belongs to the repulsive guidance molecule (RGM) family.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, GPI anchor; Transcription regulation

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: anchored to plasma membrane; ER-Golgi intermediate compartment; plasma membrane

Molecular Function:coreceptor activity; identical protein binding

Biological Process: BMP signaling pathway; cell adhesion; positive regulation of transcription, DNA-dependent; signal transduction

NCBI Summary:RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
UniProt Code:Q6NW40
NCBI GenInfo Identifier:327478562
NCBI Gene ID:285704
NCBI Accession:Q6NW40.3
UniProt Secondary Accession:Q6NW40,Q8NC92, D6R9A0,
UniProt Related Accession:Q6NW40
Molecular Weight:48kDa
NCBI Full Name:RGM domain family member B
NCBI Synonym Full Names:repulsive guidance molecule family member b
NCBI Official Symbol:RGMB  
NCBI Official Synonym Symbols:DRAGON  
NCBI Protein Information:RGM domain family member B
UniProt Protein Name:RGM domain family member B
UniProt Synonym Protein Names:DRG11-responsive axonal guidance and outgrowth of neurite; DRAGON
Protein Family:RGM domain family
UniProt Gene Name:RGMB  
Anti-RGMB Antibody (CAB12859)Western blot analysis of extracts of various cell lines, using RGMB antibody (CAB12859) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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