Anti-RGAP1 Antibody (CAB19236)

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SKU:
CAB19236
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RACGAP1
Synonyms:
CYK4
Synonyms:
HsCYK-4
Synonyms:
ID-GAP
Synonyms:
MgcRacGAP
Synonyms:
rac GTPase-activating protein 1
Research Area:
Cell Cycle

Description

Product Name:RGAP1 Rabbit mAb
Product Code:CAB19236
Size:20uL, 50uL, 100uL
Synonyms:RACGAP1, CYK4, HsCYK-4, ID-GAP, MgcRacGAP, rac GTPase-activating protein 1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human RGAP1.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, NIH/3T3, K-562, PC-12
Immunogen:Recombinant protein of human RGAP1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:29127
Uniprot:Q9H0H5
Cellular Location:Cell membrane, Cleavage furrow, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Midbody, Nucleus, Peripheral membrane protein, acrosome, cytoskeleton, secretory vesicle, spindle
Calculated MW:71kDa
Observed MW:70KDa
UniProt Protein Function:MgcRacGAP: a rac GTPase activating protein. Plays an important role in cytokinesis by regulating cortical movement through RhoA. Phosphorylation by Aurora B apparently induces GAP activity toward RhoA.
UniProt Protein Details:

Protein type:GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: nucleoplasm; microtubule; extrinsic to internal side of plasma membrane; acrosome; spindle midzone; midbody; nucleus; cytosol; cleavage furrow

Molecular Function:gamma-tubulin binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; microtubule binding; beta-tubulin binding; protein kinase binding; GTPase activator activity; alpha-tubulin binding

Biological Process: positive regulation of cytokinesis; regulation of attachment of spindle microtubules to kinetochore; spindle midzone assembly involved in mitosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; sulfate transport; microtubule-based movement; regulation of small GTPase mediated signal transduction; embryonic development; cytokinesis after mitosis; small GTPase mediated signal transduction; neuroblast proliferation; spermatogenesis; blood coagulation; cytokinesis, contractile ring formation; positive regulation of GTPase activity

NCBI Summary:The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:Q9H0H5
NCBI GenInfo Identifier:74762727
NCBI Gene ID:29127
NCBI Accession:Q9H0H5.1
UniProt Secondary Accession:Q9H0H5,Q6PJ26, Q9NWN2, Q9P250, Q9P2W2,
UniProt Related Accession:Q9H0H5
Molecular Weight:632
NCBI Full Name:Rac GTPase-activating protein 1
NCBI Synonym Full Names:Rac GTPase activating protein 1
NCBI Official Symbol:RACGAP1  
NCBI Official Synonym Symbols:CYK4; ID-GAP; HsCYK-4; MgcRacGAP  
NCBI Protein Information:rac GTPase-activating protein 1; RACGAP1; protein CYK4 homolg; protein CYK4 homolog; male germ cell RacGap; GTPase activating protein
UniProt Protein Name:Rac GTPase-activating protein 1
UniProt Synonym Protein Names:Male germ cell RacGap; MgcRacGAP; Protein CYK4 homolog; CYK4; HsCYK-4
Protein Family:Rac GTPase-activating protein
UniProt Gene Name:RACGAP1  
UniProt Entry Name:RGAP1_HUMAN
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