Cell Death Antibodies 1
Anti-RFFL Antibody (CAB13604)
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- SKU:
- CAB13604
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-RFFL Antibody |
| Antibody SKU: | CAB13604 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RFFL (NP_001017368.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RFFL (NP_001017368.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MWAT CCNW FCLD GQPE EVPP PQGA RMQA YSNP GYSS FPSP TGLE PSCK SCGA HFAN TARK QTCL DCKK NFCM TCSS QVGN GPRL CLLC QRFR ATAF QREE LMKM KVKD LRDY LSLH DIST EMCR EKEE LVLL VLGQ QPVI SQED RTRA STLS PDFP EQQA FLTQ PHSS MVPP TSPN LPSS SAQA TSVP PA |
| Gene ID: | 117584 |
| Uniprot: | Q8WZ73 |
| Cellular Location: | Cell membrane, Cytoplasm, Peripheral membrane protein, Recycling endosome membrane, cytosol |
| Calculated MW: | 36kDa/39kDa/40kDa |
| Observed MW: |
| Synonyms: | RFFL, CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L |
| Background: |
| UniProt Protein Function: | RFFL: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 17q12 Cellular Component: Golgi membrane; membrane; recycling endosome membrane; lysosome; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; endosome membrane; cytosol Molecular Function:protein binding; protease binding; zinc ion binding; p53 binding; ubiquitin protein ligase binding; protein kinase binding; ligase activity Biological Process: ubiquitin-dependent protein catabolic process; intracellular protein transport; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway |
| UniProt Code: | Q8WZ73 |
| NCBI GenInfo Identifier: | 74760639 |
| NCBI Gene ID: | 117584 |
| NCBI Accession: | Q8WZ73.1 |
| UniProt Secondary Accession: | Q8WZ73,Q8NHW0, Q8TBY7, Q96BE6, E1P633, |
| UniProt Related Accession: | Q8WZ73 |
| Molecular Weight: | 363 |
| NCBI Full Name: | E3 ubiquitin-protein ligase rififylin |
| NCBI Synonym Full Names: | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase |
| NCBI Official Symbol: | RFFL |
| NCBI Official Synonym Symbols: | CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN |
| NCBI Protein Information: | E3 ubiquitin-protein ligase rififylin; RING finger protein 189; caspase regulator CARP2; FYVE-RING finger protein SAKURA; ring finger and FYVE-like domain containing 1; caspases-8 and -10-associated RING finger protein 2; RING finger and FYVE-like domain-containing protein 1 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase rififylin |
| UniProt Synonym Protein Names: | Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; CARP-2; FYVE-RING finger protein Sakura; Fring; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | RFFL |
| UniProt Entry Name: | RFFL_HUMAN |
 | Immunofluorescence analysis of MCF-7 cells using RFFL antibody (CAB13604). Blue: DAPI for nuclear staining. |
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