Anti-Renalase Antibody (CAB19797)
- SKU:
- CAB19797
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- C10orf59
- Synonyms:
- RENALASE
Description
| Product Name: | Renalase Rabbit mAb |
| Product Code: | CAB19797 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | C10orf59, RENALASE |
| Applications: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Renalase |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse testis, Mouse kidney, Rat liver, Rat testis, Rat kidney |
| Immunogen: | A synthesized peptide derived from human Renalase |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55328 |
| Uniprot: | Q5VYX0 |
| Calculated MW: | 42kDa |
| Observed MW: | 38KDa |
| UniProt Protein Function: | RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Secreted, signal peptide; Secreted; EC 1.6.3.5 Chromosomal Location of Human Ortholog: 10q23.31 Cellular Component: extracellular space Molecular Function:oxidoreductase activity Biological Process: heart contraction; regulation of systemic arterial blood pressure; epinephrine metabolic process; phosphate ion homeostasis; norepinephrine metabolic process; dopamine metabolic process |
| NCBI Summary: | Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q5VYX0 |
| NCBI GenInfo Identifier: | 73914006 |
| NCBI Gene ID: | 55328 |
| NCBI Accession: | Q5VYX0.1 |
| UniProt Secondary Accession: | Q5VYX0,Q9BS33, Q9NUP8, |
| UniProt Related Accession: | Q5VYX0 |
| Molecular Weight: | 34,949 Da |
| NCBI Full Name: | Renalase |
| NCBI Synonym Full Names: | renalase, FAD-dependent amine oxidase |
| NCBI Official Symbol: | RNLS |
| NCBI Official Synonym Symbols: | C10orf59; RENALASE |
| NCBI Protein Information: | renalase; MAO-C; alpha-NAD(P)H oxidase/anomerase; monoamine oxidase-C |
| UniProt Protein Name: | Renalase |
| UniProt Synonym Protein Names: | Monoamine oxidase-C; MAO-C; alpha-NAD(P)H oxidase/anomerase |
| UniProt Gene Name: | RNLS |
| UniProt Entry Name: | RNLS_HUMAN |
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