Epigenetics & Nuclear Signaling Antibodies 1
Anti-REL Antibody (CAB1181)
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- SKU:
- CAB1181
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-REL Antibody |
| Antibody SKU: | CAB1181 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human REL (NP_002899.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, DU145, HL-60, Raji, Mouse heart, Mouse thymus, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human REL (NP_002899.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASG AYNP YIEI IEQP RQRG MRFR YKCE GRSA GSIP GEHS TDNN RTYP SIQI MNYY GKGK VRIT LVTK NDPY KPHP HDLV GKDC RDGY YEAE FGQE RRPL FFQN LGIR CVKK KEVK EAII TRIK AGIN PFNV PEKQ LNDI EDCD LNVV RLCF QVFL PDEH GNLT TALP PVVS NPIY DNRA PNTA ELRI CRVN KNCG SVRG GDEI FLLC DKVQ KDDI EVRF VLND WEAK GIFS QADV HRQV AIVF KTPP YCKA ITEP VTVK MQLR RPSD QEVS ESMD FRYL PDEK DTYG NKAK KQKT TLLF |
| Gene ID: | 5966 |
| Uniprot: | Q04864 |
| Cellular Location: | Nucleus |
| Calculated MW: | 65kDa/68kDa |
| Observed MW: | 68kDa |
| Synonyms: | REL, C-Rel |
| Background: | This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | REL: a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 2p13-p12 Cellular Component: cytosol; nucleoplasm; nucleus; transcription factor complex Molecular Function:chromatin binding; protein binding; transcription factor activity Biological Process: cytokine production; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; negative regulation of interferon-beta production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; response to cytokine stimulus; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q04864 |
| NCBI GenInfo Identifier: | 548720 |
| NCBI Gene ID: | 5966 |
| NCBI Accession: | Q04864.1 |
| UniProt Secondary Accession: | Q04864,Q17RU2, Q2PNZ7, Q6LDY0, |
| UniProt Related Accession: | Q04864 |
| Molecular Weight: | 65,225 Da |
| NCBI Full Name: | Proto-oncogene c-Rel |
| NCBI Synonym Full Names: | v-rel avian reticuloendotheliosis viral oncogene homolog |
| NCBI Official Symbol: | REL |
| NCBI Official Synonym Symbols: | C-Rel |
| NCBI Protein Information: | proto-oncogene c-Rel |
| UniProt Protein Name: | Proto-oncogene c-Rel |
| Protein Family: | Nuclear factor |
| UniProt Gene Name: | REL |
| UniProt Entry Name: | REL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using REL antibody (CAB1181) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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