Immunology Antibodies 2
Anti-REG3A Antibody (CAB2101)
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- SKU:
- CAB2101
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-REG3A Antibody |
| Antibody SKU: | CAB2101 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-175 of human REG3A (NP_002571.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, Raji, HT-29, SW480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-175 of human REG3A (NP_002571.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EEPQ RELP SARI RCPK GSKA YGSH CYAL FLSP KSWT DADL ACQK RPSG NLVS VLSG AEGS FVSS LVKS IGNS YSYV WIGL HDPT QGTE PNGE GWEW SSSD VMNY FAWE RNPS TISS PGHC ASLS RSTA FLRW KDYN CNVR LPYV CKFT D |
| Gene ID: | 5068 |
| Uniprot: | Q06141 |
| Cellular Location: | Secreted |
| Calculated MW: | 19kDa |
| Observed MW: | 15kDa |
| Synonyms: | REG3A, HIP, HIP/PAP, INGAP, PAP, PAP-H, PAP1, PBCGF, REG-III, REG3 |
| Background: | This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein. |
| UniProt Protein Function: | REG3A: Might be a stress protein involved in the control of bacterial proliferation. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p12 Cellular Component: extracellular space; cytoplasm Molecular Function:carbohydrate binding Biological Process: heterophilic cell adhesion; cell proliferation; multicellular organismal development; negative regulation of keratinocyte differentiation; acute-phase response |
| NCBI Summary: | This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014] |
| UniProt Code: | Q06141 |
| NCBI GenInfo Identifier: | 464341 |
| NCBI Gene ID: | 5068 |
| NCBI Accession: | Q06141.1 |
| UniProt Related Accession: | Q06141 |
| Molecular Weight: | 175 |
| NCBI Full Name: | Regenerating islet-derived protein 3-alpha |
| NCBI Synonym Full Names: | regenerating islet-derived 3 alpha |
| NCBI Official Symbol: | REG3A |
| NCBI Official Synonym Symbols: | HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III |
| NCBI Protein Information: | regenerating islet-derived protein 3-alpha; REG-3-alpha; reg III-alpha; PAP homologous protein; human proislet peptide; pancreatitis-associated protein 1; proliferation-inducing protein 34; proliferation-inducing protein 42; hepatocarcinoma-intestine-pancreas; pancreatic beta cell growth factor; hepatointestinal pancreatic protein; regenerating islet-derived protein III-alpha |
| UniProt Protein Name: | Regenerating islet-derived protein 3-alpha |
| UniProt Synonym Protein Names: | Hepatointestinal pancreatic protein; HIP/PAP; Human proislet peptide; Pancreatitis-associated protein 1; Regenerating islet-derived protein III-alpha; Reg III-alpha |
| Protein Family: | Regenerating islet-derived protein |
| UniProt Gene Name: | REG3A |
| UniProt Entry Name: | REG3A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using REG3A antibody (CAB2101) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat lung using REG3A antibody (CAB2101) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using REG3A antibody (CAB2101) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse stomach using REG3A antibody (CAB2101) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of MCF-7 cells using REG3A antibody (CAB2101). Blue: DAPI for nuclear staining. |
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