Cell Biology Antibodies 9
Anti-REG1A Antibody (CAB5327)
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- SKU:
- CAB5327
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-REG1A Antibody |
| Antibody SKU: | CAB5327 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human REG1A (NP_002900.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, K-562, Mouse kidney, Mouse intestine, Mouse lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human REG1A (NP_002900.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FNED RETW VDAD LYCQ NMNS GNLV SVLT QAEG AFVA SLIK ESGT DDFN VWIG LHDP KKNR RWHW SSGS LVSY KSWG IGAP SSVN PGYC VSLT SSTG FQKW K |
| Gene ID: | 5967 |
| Uniprot: | P05451 |
| Cellular Location: | Secreted |
| Calculated MW: | 18kDa |
| Observed MW: | 25kDa |
| Synonyms: | REG1A, ICRF, P19, PSP, PSPS, PSPS1, PTP, REG |
| Background: | This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. |
| UniProt Protein Function: | REG1A: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 2p12 Molecular Function:growth factor activity; carbohydrate binding Biological Process: positive regulation of cell proliferation |
| NCBI Summary: | This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05451 |
| NCBI GenInfo Identifier: | 131433 |
| NCBI Gene ID: | 5967 |
| NCBI Accession: | P05451.3 |
| UniProt Related Accession: | P05451 |
| Molecular Weight: | |
| NCBI Full Name: | Lithostathine-1-alpha |
| NCBI Synonym Full Names: | regenerating family member 1 alpha |
| NCBI Official Symbol: | REG1A |
| NCBI Official Synonym Symbols: | P19; PSP; PTP; REG; ICRF; PSPS; PSPS1 |
| NCBI Protein Information: | lithostathine-1-alpha |
| UniProt Protein Name: | Lithostathine-1-alpha |
| UniProt Synonym Protein Names: | Islet cells regeneration factor; ICRF; Islet of Langerhans regenerating protein; REG; Pancreatic stone protein; PSP; Pancreatic thread protein; PTP; Regenerating islet-derived protein 1-alpha; REG-1-alpha; Regenerating protein I alpha |
| Protein Family: | Lithostathine |
| UniProt Gene Name: | REG1A |
| UniProt Entry Name: | REG1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using REG1A antibody (CAB5327) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 60s. |
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