Cell Biology Antibodies 5
Anti-RDX Antibody (CAB14777)
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- SKU:
- CAB14777
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RDX Antibody |
| Antibody SKU: | CAB14777 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RDX (NP_002897.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HeLa, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RDX (NP_002897.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPKP INVR VTTM DAEL EFAI QPNT TGKQ LFDQ VVKT VGLR EVWF FGLQ YVDS KGYS TWLK LNKK VTQQ DVKK ENPL QFKF RAKF FPED VSEE LIQE ITQR LFFL QVKE AILN DEIY CPPE TAVL LASY AVQA KYGD YNKE IHKP GYLA NDRL LPQR VLEQ HKLT KEQW EERI QNWH EEHR GMLR EDSM MEYL KIAQ DLEM |
| Gene ID: | 5962 |
| Uniprot: | P35241 |
| Cellular Location: | Cell membrane, Cleavage furrow, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton |
| Calculated MW: | 23kDa/29kDa/52kDa/68kDa/71kDa |
| Observed MW: | 80kDa |
| Synonyms: | RDX, DFNB24, radixin |
| Background: | Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Radixin: a cytoskeletal protein of the ERM family which includes ezrin and moiesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. May play a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q23 Cellular Component: apical plasma membrane; cortical actin cytoskeleton; extracellular space; filopodium; focal adhesion; lamellipodium; microvillus; plasma membrane Molecular Function:actin binding; ATPase binding; protein binding; protein homodimerization activity; protein kinase A binding Biological Process: establishment of protein localization; negative regulation of cell size; negative regulation of homotypic cell-cell adhesion; positive regulation of cell migration; regulation of actin filament bundle formation; regulation of cell shape; regulation of cell size; regulation of GTPase activity; regulation of Rap protein signal transduction Disease: Deafness, Autosomal Recessive 24 |
| NCBI Summary: | Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | P35241 |
| NCBI GenInfo Identifier: | 464541 |
| NCBI Gene ID: | 5962 |
| NCBI Accession: | P35241.1 |
| UniProt Secondary Accession: | P35241,Q86Y61, A7YIJ8, A7YIK0, A7YIK3, B7Z9U6, F5H1A7 |
| UniProt Related Accession: | P35241 |
| Molecular Weight: | 71,049 Da |
| NCBI Full Name: | Radixin |
| NCBI Synonym Full Names: | radixin |
| NCBI Official Symbol: | RDX |
| NCBI Official Synonym Symbols: | DFNB24 |
| NCBI Protein Information: | radixin |
| UniProt Protein Name: | Radixin |
| Protein Family: | Radixin |
| UniProt Gene Name: | RDX |
| UniProt Entry Name: | RADI_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RDX antibody (CAB14777) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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