Cell Biology Antibodies 17

Anti-RDH11 Antibody (CAB18454)

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SKU:
CAB18454
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RDH11 Antibody
Antibody SKU:CAB18454
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human RDH11.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:PC-3, HepG2
Immunogen:Recombinant protein of human RDH11.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:51109
Uniprot:Q8TC12
Cellular Location:
Calculated MW:
Observed MW:35kDa
Anti-RDH11 Antibody (CAB18454)Western blot - RDH11 Rabbit pAb (CAB18454)
Synonyms:ARSDR1, CGI82, HCBP12, MDT1, PSDR1, RALR1, RDJCSS, SCALD, SDR7C1, RDH11
Background:
UniProt Protein Function:RDH11: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; EC 1.1.1.300

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: endoplasmic reticulum membrane; photoreceptor inner segment; integral to membrane; intracellular

Molecular Function:retinol dehydrogenase activity

Biological Process: phototransduction, visible light; retinal metabolic process; retinol metabolic process; adaptation of rhodopsin mediated signaling; retinoid metabolic process

Disease: Retinal Dystrophy, Juvenile Cataracts, And Short Stature Syndrome

NCBI Summary:The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]
UniProt Code:Q8TC12
NCBI GenInfo Identifier:90110515
NCBI Gene ID:51109
NCBI Accession:ABD90542.1
UniProt Secondary Accession:Q8TC12,Q6IAH5, Q9NRW0, Q9Y391, A6NDK3, A8K062, B2RB26 B4DDW0,
UniProt Related Accession:Q8TC12
Molecular Weight:35,386 Da
NCBI Full Name:retinol dehydrogenase 11, partial
NCBI Synonym Full Names:retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
NCBI Official Symbol:RDH11  
NCBI Official Synonym Symbols:MDT1; CGI82; PSDR1; RALR1; SCALD; ARSDR1; HCBP12; SDR7C1  
NCBI Protein Information:retinol dehydrogenase 11; retinal reductase 1; HCV core-binding protein HCBP12; prostate short-chain dehydrogenase reductase 1; prostate short-chain dehydrogenase/reductase 1; short chain dehydrogenase/reductase family 7C, member 1; androgen-regulated short-chain dehydrogenase/reductase 1
UniProt Protein Name:Retinol dehydrogenase 11
UniProt Synonym Protein Names:Androgen-regulated short-chain dehydrogenase/reductase 1; HCV core-binding protein HCBP12; Prostate short-chain dehydrogenase/reductase 1; Retinal reductase 1
Protein Family:Retinol dehydrogenase
UniProt Gene Name:RDH11  
UniProt Entry Name:RDH11_HUMAN
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