Immunology Antibodies 1
Anti-RCOR1 Antibody (CAB12845)
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- SKU:
- CAB12845
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-RCOR1 Antibody |
| Antibody SKU: | CAB12845 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 256-485 of human RCOR1 (NP_055971.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Jurkat, Mouse testis, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 256-485 of human RCOR1 (NP_055971.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EREE SEDE LEEA NGNN PIDI EVDQ NKES KKEV PPTE TVPQ VKKE KHST QAKN RAKR KPPK GMFL SQED VEAV SANA TAAT TVLR QLDM ELVS VKRQ IQNI KQTN SALK EKLD GGIE PYRL PEVI QKCN ARWT TEEQ LLAV QAIR KYGR DFQA ISDV IGNK SVVQ VKNF FVNY RRRF NIDE VLQE WEAE HGKE ETNG PSNQ KPVK SPDN SIKM PEEE DEAP VLDV RYAS AS |
| Gene ID: | 23186 |
| Uniprot: | Q9UKL0 |
| Cellular Location: | Nucleus |
| Calculated MW: | 53kDa |
| Observed MW: | 60kDa |
| Synonyms: | RCOR1, COREST, RCOR |
| Background: | This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). |
| UniProt Protein Function: | RCOR1: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Belongs to the CoREST family. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 14q32.31 Cellular Component: nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex Molecular Function:histone deacetylase activity; protein binding; transcription corepressor activity; transcription factor binding Biological Process: blood coagulation; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9UKL0 |
| NCBI GenInfo Identifier: | 74762776 |
| NCBI Gene ID: | 23186 |
| NCBI Accession: | Q9UKL0.1 |
| UniProt Secondary Accession: | Q9UKL0,Q15044, Q6P2I9, Q86VG5, |
| UniProt Related Accession: | Q9UKL0 |
| Molecular Weight: | 53,028 Da |
| NCBI Full Name: | REST corepressor 1 |
| NCBI Synonym Full Names: | REST corepressor 1 |
| NCBI Official Symbol: | RCOR1 |
| NCBI Official Synonym Symbols: | RCOR; COREST |
| NCBI Protein Information: | REST corepressor 1 |
| UniProt Protein Name: | REST corepressor 1 |
| UniProt Synonym Protein Names: | Protein CoREST |
| Protein Family: | REST corepressor |
| UniProt Gene Name: | RCOR1 |
| UniProt Entry Name: | RCOR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CoREST/CoREST/RCOR1 antibody at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s. |
 | Immunoprecipitation analysis of 300ug extracts of Jurkat cells using 3ug CoREST/RCOR1 antibody at a dilition of 1:1000. |
 | Chromatin immunoprecipitation analysis of extracts of HepG2 cells, using CoREST/RCOR1 antibody and rabbit IgG. The amount of immunoprecipitated DNA was checked by quantitative PCR. Histogram was constructed by the ratios of the immunoprecipitated DNA to the input. |
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